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Familial hypercholesterolaemia: cholesterol efflux and coronary disease

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  • Jorie Versmissen
  • Ranitha Vongpromek
  • Reyhana Yahya
  • Jeroen B van der Net
  • Leonie van Vark-van der Zee
  • Jeannette Blommesteijn-Touw
  • Darcos Wattimena
  • Trinet Rietveld
  • Clive R Pullinger
  • Christina Christoffersen
  • Björn Dahlbäck
  • John P Kane
  • Monique Mulder
  • Eric J G Sijbrands
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BACKGROUND: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux.

MATERIALS AND METHODS: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM).

RESULTS: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the FH patients without CHD was 16 ± 22% (mean ± SD) higher and to plasma from the FH patients with CHD was 7 ± 8% lower (P = 0·03, CHD vs. non-CHD). Compared to their non-FH brothers, FH patients without CHD displayed significantly higher levels of HDL-cholesterol, HDL-S1P and apoM, while FH patients with CHD displayed lower levels than their non-FH brothers.

CONCLUSIONS: A higher plasma cholesterol efflux capacity and higher S1P and apoM content of HDL in asymptomatic FH patients may play a role in their apparent protection from premature CHD.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Clinical Investigation
Vol/bind46
Udgave nummer7
Sider (fra-til)643-50
Antal sider8
ISSN0014-2972
DOI
StatusUdgivet - jul. 2016

ID: 49289744