Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Familial confounding of the association between maternal smoking in pregnancy and autism spectrum disorder in offspring

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Do cognitive deficits persist into adolescence in autism?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Auditory processing in autism spectrum disorder: Mismatch negativity deficits

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Exploring 'The autisms' at a cognitive level

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Normal P50 Gating in Children with Autism, Yet Attenuated P50 Amplitude in the Asperger Subcategory

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Increased Prepulse Inhibition and Sensitization of the Startle Reflex in Autistic Children

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Genetics of Anxiety Disorders

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. The association between neonatal vitamin D status and risk of schizophrenia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Attention-deficit hyperactivity disorder and anxiety disorders as precursors of bipolar disorder onset in adulthood

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Amy E Kalkbrenner
  • Sandra M Meier
  • Paul Madley-Dowd
  • Christine Ladd-Acosta
  • Margaret Daniele Fallin
  • Erik Parner
  • Diana Schendel
Vis graf over relationer

Evidence supports no link between maternal smoking in pregnancy and autism spectrum disorder (autism) overall. To address remaining questions about the unexplained heterogeneity between study results and the possibility of risk for specific autism sub-phenotypes, we conducted a whole-population cohort study in Denmark. We followed births 1991-2011 (1,294,906 persons, including 993,301 siblings in 728,271 families), from 1 year of age until an autism diagnosis (13,547), death, emigration, or December 31, 2012. Autism, with and without attention deficit hyperactivity disorder (ADHD) and with and without intellectual disability (ID) were based on ICD-8 and ICD-10 codes from Danish national health registers, including 3,319 autism + ADHD, 10,228 autism - no ADHD, 2,205 autism + ID, and 11,342 autism - no ID. We estimated hazard ratios (HRs) and 95% confidence intervals (95% CIs) between any maternal smoking (from birth records) and autism (or sub-phenotypes) using survival models with robust standard errors, stratifying by birth year and adjusting for child sex, parity, and parental age, education, income, and psychiatric history. To additionally address confounding using family designs, we constructed a maternal cluster model (adjusting for the smoking proportion within the family), and a stratified sibling model. Associations with maternal smoking and autism were elevated in conventional adjusted analyses (HR of 1.17 [1.13-1.22]) but attenuated in the maternal cluster (0.98 [0.88-1.09]) and sibling (0.86 [0.64-1.15]) models. Similarly, risks of autism sub-phenotypes with maternal smoking were attenuated in the family-based models. Together these results support that smoking in pregnancy is not linked with autism or select autism comorbid sub-phenotypes after accounting for familial confounding. Autism Res 2019. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Smoking during pregnancy has many harmful impacts, which may include harming the baby's developing brain. However, in a study of thousands of families in Denmark, it does not appear that smoking in pregnancy leads to autism or autism in combination with intellectual problems or attention deficits, once you account for the way smoking patterns and developmental disabilities run in families.

OriginalsprogEngelsk
TidsskriftAutism Research
ISSN1939-3792
DOI
StatusE-pub ahead of print - 29 aug. 2019

Bibliografisk note

© 2019 International Society for Autism Research, Wiley Periodicals, Inc.

ID: 57933785