Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Familial Clustering of Aortic Size, Aneurysms, and Dissections in the Community

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Improving colonoscopy quality through individualised training programmes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Smartphone Activation of Citizen Responders to Facilitate Defibrillation in Out-of-Hospital Cardiac Arrest

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Add-on therapy in metformin-treated patients with type 2 diabetes at moderate cardiovascular risk: a nationwide study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Age-specific trends in incidence and survival of out-of-hospital cardiac arrest from presumed cardiac cause in Denmark 2002-2014

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Background: Ruptured aortic aneurysm and aortic dissections are potentially preventable disorders associated with high mortality. Screening of individuals at risk may translate into elective surgical interventions and lowered mortality. It is uncertain if the risk of aortic dilation of varying degrees aggregates within families. Methods: We investigated the risk of having thoracic and abdominal aortic sizes in the highest quartile (measured by computed tomography scans and indexed for body size) if at least one parent did so in the Framingham Heart Study (FHS) cohorts, and estimated the incidence rates and hazards ratio of developing aortic aneurysm or dissection among first-degree relatives of those with aortic aneurysm or dissection, as compared with age- and sex-matched controls (1:10 for aortic aneurysm and 1:100 for aortic dissection) using the Danish nationwide administrative registries. Results: In FHS, offspring (n=235) whose parent(s) had a sex- and age-standardized aortic size in the upper quartile had a multivariable-adjusted ~3-fold increased odds ratio of belonging to the upper quartile themselves. In Denmark, a total of 68,939 individuals (mean age 42 years) had a first-degree relative with aortic aneurysm and 7,209 persons (mean age 39 years) had a firstdegree relative with aortic dissection. During an average follow-up of 7 years, first-degree relatives of patients with aortic aneurysm and dissection had a hazards ratio of 6.70 (95% CI 5.96-7.52) for developing aortic aneurysm and 9.24 (95% CI 5.53-15.44) for dissection, compared to matched controls. These estimates remained unchanged upon adjusting for several comorbidities, including prevalent hypertension, bicuspid aortic valve, and the Marfan syndrome. For both aortic aneurysm and dissections, the absolute event rates approached 1 per 1000 person-years for first-degree relatives versus 11-13 (aortic aneurysm) and 2-3 (aortic dissections) per 100,000 person-years among controls. Conclusions: Increased aortic size, a precursor of aortic aneurysm and a risk factor for dissection, clusters in families. The incidence rates of aortic aneurysm and dissections approach that of other common cardiovascular conditions in first-degree relatives, supporting the use of systematic screening for these conditions.

OriginalsprogEngelsk
TidsskriftCirculation
ISSN0009-7322
DOI
StatusE-pub ahead of print - 25 jun. 2020

ID: 60284520