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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Familial adenomatous polyposis.

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  1. Colorectal Cancer in Individuals With Familial Adenomatous Polyposis, Based on Analysis of the Danish Polyposis Registry

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  2. A proposed staging system and stage-specific interventions for familial adenomatous polyposis

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Vis graf over relationer
Familial adenomatous polyposis is an autosomal dominant disease that includes early development of up to thousands of colorectal adenomas and several extracolonic manifestations. All untreated patients will develop colorectal adenocarcinoma. The treatment of choice is colectomy and ileorectal anastomosis, but restorative proctocolectomy may be considered in selected cases. Polyposis patients treated with ileorectal anastomosis should be followed for life, with regular proctosigmoidoscopy and destruction of new adenomas. Furthermore, regular gastroduodenoscopy should be carried out because of frequent occurrence of premalignant duodenal adenomas. The prognosis is good after prophylactic colectomy in patients without carcinoma. All first degree relatives of affected family members should be examined regularly with proctosigmoidoscopy from the age of ten, and prophylaxis should be organised using a national or regional polyposis register. The recent detection of a specific gene for familial adenomatous polyposis is a long step forward, and several problems may be solved by increasing international cooperation.
Bidragets oversatte titelFamilial adenomatous polyposis.
OriginalsprogEngelsk
TidsskriftAnnals of Medicine
Vol/bind21
Udgave nummer4
Sider (fra-til)299-307
Antal sider9
ISSN0785-3890
StatusUdgivet - 1989

ID: 32544343