Familiaer hemiplegisk migraene

L L Thomsen, J Olesen, M B Russell

Abstract

Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura. It is inherited as an autosomal dominant trait. A gene for FHM has been assigned to chromosome 19. This gene codes for a brain-specific calcium channel, and is responsible for FHM in 55% of the FHM families. Other FHM families have been linked to two different locations on chromosome 1. These locations contain possible candidate genes coding for calcium-and potassium channels. Thus FHM is a genetically heterogenous ion channel disorder, which is caused by at least three different genes. About 29% of the FHM families also have cerebellar ataxia, these families have all been linked to chromosome 19. The identification of the genes for FHM may be a key to the identification of the gene/genes for migraine with and without aura.

Bidragets oversatte titelFamilial hemiplegic migraine
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind160
Udgave nummer37
Sider (fra-til)5325-9
Antal sider5
ISSN0041-5782
StatusUdgivet - 7 sep. 1998
Udgivet eksterntJa

Emneord

  • Chromosome Mapping
  • Female
  • Hemiplegia/diagnosis
  • Humans
  • Male
  • Migraine Disorders/diagnosis
  • Pedigree

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