Factors Associated With Plasma IL-6 Levels During HIV Infection

Álvaro H Borges, Jemma L O'Connor, Andrew N Phillips, Frederikke F Rönsholt, Sarah Pett, Michael J Vjecha, Martyn A French, Jens D Lundgren, INSIGHT SMART and ESPRIT Study Groups and the SILCAAT Scientific Committee

    133 Citationer (Scopus)

    Abstract

    BACKGROUND: Elevated interleukin 6 (IL-6) levels have been linked to cardiovascular disease, cancer and death. Persons with human immunodeficiency virus (HIV) infection receiving treatment have higher IL-6 levels, but few data are available on factors associated with circulating IL-6.

    METHODS: Participants in 3 trials with IL-6 measured at baseline were included (N = 9864). Factors associated with IL-6 were identified by linear regression. Demographic and HIV variables (nadir/entry CD4(+) cell count, HIV RNA level, antiretroviral therapy regimen) were investigated in all 3 trials. In the SMART (Strategies for Management of Anti-Retroviral Therapy) trial, CD4/CD8 ratio, smoking, comorbid conditions, serum lipids, renal function (estimated glomerular filtration rate [eGFR]), and educational level were assessed.

    RESULTS: Demographics associated with higher IL-6 levels were older age and lower education, whereas black race was associated with lower IL-6. Higher HIV RNA levels were associated with higher IL-6 levels, and higher nadir CD4(+) cell counts with lower IL-6 levels. Compared with efavirenz, protease inhibitors were associated with higher and nevirapine with lower IL-6 levels. Smoking and all comorbid conditions were related to higher IL-6. IL-6 levels increased with decreasing eGFR and decreasing serum lipids.

    CONCLUSIONS: Higher levels of IL-6 were associated with older age, nonblack race, higher body mass index, lower serum lipid levels, HIV replication, low nadir CD4(+) cell count, protease inhibitor use, comorbid conditions, and decreased eGFR. Multiple factors affect inflammation in HIV and should be considered in studies of IL-6 as a biomarker of clinical outcomes.

    OriginalsprogEngelsk
    TidsskriftThe Journal of infectious diseases
    Vol/bind212
    Udgave nummer4
    Sider (fra-til)585-95
    Antal sider11
    ISSN0022-1899
    DOI
    StatusUdgivet - 15 aug. 2015

    Fingeraftryk

    Dyk ned i forskningsemnerne om 'Factors Associated With Plasma IL-6 Levels During HIV Infection'. Sammen danner de et unikt fingeraftryk.

    Citationsformater