Ex vivo intestinal adhesion of Escherichia coli LF82 in Crohn's disease

Stina Rikke Jensen, Lisbeth Nielsen Fink, Ole Haagen Nielsen, Jørn Brynskov, Susanne Brix

11 Citationer (Scopus)

Abstract

Adherent-invasive Escherichia coli (AIEC) are reported to inhabit the gut mucosa in Crohn's disease (CD), however, little is known about the importance of host factors for the interplay between AIEC and the human gut. To examine if differences in bacterial adhesion patterns are disease associated, the AIEC-prototype strain LF82 was evaluated for its ability to adhere to ileal and colonic biopsies from CD and healthy controls (HC). Moreover, the efficacy of the non-pathogenic E. coli Nissle 1917 (ECN) in averting LF82 adhesion to ileal mucosa was assessed. Similar numbers of LF82 adhered to biopsies from CD and HC. A significantly greater LF82 attachment to ileal versus colonic mucosa was found in HC (P 
OriginalsprogEngelsk
TidsskriftMicrobial Pathogenesis
Vol/bind51
Udgave nummer6
Sider (fra-til)426-31
Antal sider6
ISSN0882-4010
DOI
StatusUdgivet - 2011

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