TY - JOUR
T1 - Extreme neonatal hyperbilirubinemia and kernicterus spectrum disorder in Denmark during the years 2000-2015
AU - Donneborg, Mette Line
AU - Hansen, Bo Moelholm
AU - Vandborg, Pernille Kure
AU - Rodrigo-Domingo, María
AU - Ebbesen, Finn
PY - 2020/2
Y1 - 2020/2
N2 - OBJECTIVE: To determine the incidence and etiology of extreme neonatal hyperbilirubinemia, defined as total serum bilirubin (TSB) ≥450 µmol/L, and kernicterus spectrum disorder (KSD) in Denmark between 2000 and 2015.STUDY DESIGN: We identified all infants born between 01.01.2000 and 31.12.2015 with TSB ≥450 µmol/L, ratio of conjugated to TSB <0.30, gestational age ≥35 weeks, and postnatal age ≤4 weeks, using Danish hospitals' laboratory databases.RESULT: We included 408 infants. The incidence of extreme neonatal hyperbilirubinemia among infants with gestational age ≥35 weeks was 42/100,000 during the study period with a seemingly decreasing incidence between 2005 and 2015. Twelve of the 408 infants developed KSD, (incidence 1.2/100,000) Blood type ABO isohemolytic disease was the most common explanatory etiology.CONCLUSIONS: Our study stresses the importance of a systematic approach to neonatal jaundice and ongoing surveillance of extreme neonatal hyperbilirubinemia and KSD.
AB - OBJECTIVE: To determine the incidence and etiology of extreme neonatal hyperbilirubinemia, defined as total serum bilirubin (TSB) ≥450 µmol/L, and kernicterus spectrum disorder (KSD) in Denmark between 2000 and 2015.STUDY DESIGN: We identified all infants born between 01.01.2000 and 31.12.2015 with TSB ≥450 µmol/L, ratio of conjugated to TSB <0.30, gestational age ≥35 weeks, and postnatal age ≤4 weeks, using Danish hospitals' laboratory databases.RESULT: We included 408 infants. The incidence of extreme neonatal hyperbilirubinemia among infants with gestational age ≥35 weeks was 42/100,000 during the study period with a seemingly decreasing incidence between 2005 and 2015. Twelve of the 408 infants developed KSD, (incidence 1.2/100,000) Blood type ABO isohemolytic disease was the most common explanatory etiology.CONCLUSIONS: Our study stresses the importance of a systematic approach to neonatal jaundice and ongoing surveillance of extreme neonatal hyperbilirubinemia and KSD.
KW - Bilirubin/blood
KW - Cohort Studies
KW - Denmark/epidemiology
KW - Exchange Transfusion, Whole Blood
KW - Female
KW - Gestational Age
KW - Glucosephosphate Dehydrogenase Deficiency/epidemiology
KW - Humans
KW - Hyperbilirubinemia, Neonatal/complications
KW - Incidence
KW - Infant, Newborn
KW - Jaundice, Neonatal
KW - Kernicterus/diagnosis
KW - Magnetic Resonance Imaging
KW - Male
KW - Phototherapy
U2 - 10.1038/s41372-019-0566-8
DO - 10.1038/s41372-019-0566-8
M3 - Journal article
C2 - 31907395
SN - 0743-8346
VL - 40
SP - 194
EP - 202
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 2
ER -