Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls

Walter Koch; Marcus Unterrainer; Guoming Xiong; Peter Bartenstein; Markus Diemling; Andrea Varrone; John C Dickson; Livia Tossici-Bolt; Terez Sera; Susanne Asenbaum; Jan Booij; Ozlem L Kapucu; Andreas Kluge; Morten Ziebell; Jacques Darcourt; Flavio Nobili; Marco Pagani; Swen Hesse; Thierry Vander Borght; Koen Van Laere; Klaus Tatsch; Christian la Fougère

doi:10.1007/s00259-014-2785-8

Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls

Walter Koch, Marcus Unterrainer, Guoming Xiong, Peter Bartenstein, Markus Diemling, Andrea Varrone, John C Dickson, Livia Tossici-Bolt, Terez Sera, Susanne Asenbaum, Jan Booij, Ozlem L Kapucu, Andreas Kluge, Morten Ziebell, Jacques Darcourt, Flavio Nobili, Marco Pagani, Swen Hesse, Thierry Vander Borght, Koen Van LaereKlaus Tatsch, Christian la Fougère

Afdeling for Hjerne- og Nervesygdomme

54 Citationer (Scopus)

Abstrakt

PURPOSE: Apart from binding to the dopamine transporter (DAT), [(123)I]FP-CIT shows moderate affinity for the serotonin transporter (SERT), allowing imaging of both monoamine transporters in a single imaging session in different brain areas. The aim of this study was to systematically evaluate extrastriatal binding (predominantly due to SERT) and its age and gender dependencies in a large cohort of healthy controls.

METHODS: SPECT data from 103 healthy controls with well-defined criteria of normality acquired at 13 different imaging centres were analysed for extrastriatal binding using volumes of interest analysis for the thalamus and the pons. Data were examined for gender and age effects as well as for potential influence of striatal DAT radiotracer binding.

RESULTS: Thalamic binding was significantly higher than pons binding. Partial correlations showed an influence of putaminal DAT binding on measured binding in the thalamus but not on the pons. Data showed high interindividual variation in extrastriatal binding. Significant gender effects with 31 % higher binding in women than in men were observed in the thalamus, but not in the pons. An age dependency with a decline per decade (±standard error) of 8.2 ± 1.3 % for the thalamus and 6.8 ± 2.9 % for the pons was shown.

CONCLUSION: The potential to evaluate extrastriatal predominant SERT binding in addition to the striatal DAT in a single imaging session was shown using a large database of [(123)I]FP-CIT scans in healthy controls. For both the thalamus and the pons, an age-related decline in radiotracer binding was observed. Gender effects were demonstrated for binding in the thalamus only. As a potential clinical application, the data could be used as a reference to estimate SERT occupancy in addition to nigrostriatal integrity when using [(123)I]FP-CIT for DAT imaging in patients treated with selective serotonin reuptake inhibitors.

Originalsprog	Engelsk
Tidsskrift	European Journal of Nuclear Medicine and Molecular Imaging
Vol/bind	41
Udgave nummer	10
Sider (fra-til)	1938-46
Antal sider	9
ISSN	1619-7070
DOI	https://doi.org/10.1007/s00259-014-2785-8
Status	Udgivet - okt. 2014

Adgang til dokumentet

10.1007/s00259-014-2785-8

Citationsformater

Koch, W., Unterrainer, M., Xiong, G., Bartenstein, P., Diemling, M., Varrone, A., Dickson, J. C., Tossici-Bolt, L., Sera, T., Asenbaum, S., Booij, J., Kapucu, O. L., Kluge, A., Ziebell, M., Darcourt, J., Nobili, F., Pagani, M., Hesse, S., Vander Borght, T., ... la Fougère, C. (2014). Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls. European Journal of Nuclear Medicine and Molecular Imaging, 41(10), 1938-46. https://doi.org/10.1007/s00259-014-2785-8

Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons : gender and age dependencies assessed in a European multicentre database of healthy controls. / Koch, Walter; Unterrainer, Marcus; Xiong, Guoming et al.

I: European Journal of Nuclear Medicine and Molecular Imaging, Bind 41, Nr. 10, 10.2014, s. 1938-46.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Koch, W, Unterrainer, M, Xiong, G, Bartenstein, P, Diemling, M, Varrone, A, Dickson, JC, Tossici-Bolt, L, Sera, T, Asenbaum, S, Booij, J, Kapucu, OL, Kluge, A, Ziebell, M, Darcourt, J, Nobili, F, Pagani, M, Hesse, S, Vander Borght, T, Van Laere, K, Tatsch, K & la Fougère, C 2014, 'Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls', European Journal of Nuclear Medicine and Molecular Imaging, bind 41, nr. 10, s. 1938-46. https://doi.org/10.1007/s00259-014-2785-8

@article{15435f70c98b447d927284505fe98310,

title = "Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls",

abstract = "PURPOSE: Apart from binding to the dopamine transporter (DAT), [(123)I]FP-CIT shows moderate affinity for the serotonin transporter (SERT), allowing imaging of both monoamine transporters in a single imaging session in different brain areas. The aim of this study was to systematically evaluate extrastriatal binding (predominantly due to SERT) and its age and gender dependencies in a large cohort of healthy controls.METHODS: SPECT data from 103 healthy controls with well-defined criteria of normality acquired at 13 different imaging centres were analysed for extrastriatal binding using volumes of interest analysis for the thalamus and the pons. Data were examined for gender and age effects as well as for potential influence of striatal DAT radiotracer binding.RESULTS: Thalamic binding was significantly higher than pons binding. Partial correlations showed an influence of putaminal DAT binding on measured binding in the thalamus but not on the pons. Data showed high interindividual variation in extrastriatal binding. Significant gender effects with 31 % higher binding in women than in men were observed in the thalamus, but not in the pons. An age dependency with a decline per decade (±standard error) of 8.2 ± 1.3 % for the thalamus and 6.8 ± 2.9 % for the pons was shown.CONCLUSION: The potential to evaluate extrastriatal predominant SERT binding in addition to the striatal DAT in a single imaging session was shown using a large database of [(123)I]FP-CIT scans in healthy controls. For both the thalamus and the pons, an age-related decline in radiotracer binding was observed. Gender effects were demonstrated for binding in the thalamus only. As a potential clinical application, the data could be used as a reference to estimate SERT occupancy in addition to nigrostriatal integrity when using [(123)I]FP-CIT for DAT imaging in patients treated with selective serotonin reuptake inhibitors.",

author = "Walter Koch and Marcus Unterrainer and Guoming Xiong and Peter Bartenstein and Markus Diemling and Andrea Varrone and Dickson, {John C} and Livia Tossici-Bolt and Terez Sera and Susanne Asenbaum and Jan Booij and Kapucu, {Ozlem L} and Andreas Kluge and Morten Ziebell and Jacques Darcourt and Flavio Nobili and Marco Pagani and Swen Hesse and {Vander Borght}, Thierry and {Van Laere}, Koen and Klaus Tatsch and {la Foug{\`e}re}, Christian",

year = "2014",

month = oct,

doi = "10.1007/s00259-014-2785-8",

language = "English",

volume = "41",

pages = "1938--46",

journal = "European Journal Of Nuclear Medicine",

issn = "1619-7070",

publisher = "Springer",

number = "10",

}

TY - JOUR

T1 - Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons

T2 - gender and age dependencies assessed in a European multicentre database of healthy controls

AU - Koch, Walter

AU - Unterrainer, Marcus

AU - Xiong, Guoming

AU - Bartenstein, Peter

AU - Diemling, Markus

AU - Varrone, Andrea

AU - Dickson, John C

AU - Tossici-Bolt, Livia

AU - Sera, Terez

AU - Asenbaum, Susanne

AU - Booij, Jan

AU - Kapucu, Ozlem L

AU - Kluge, Andreas

AU - Ziebell, Morten

AU - Darcourt, Jacques

AU - Nobili, Flavio

AU - Pagani, Marco

AU - Hesse, Swen

AU - Vander Borght, Thierry

AU - Van Laere, Koen

AU - Tatsch, Klaus

AU - la Fougère, Christian

PY - 2014/10

Y1 - 2014/10

N2 - PURPOSE: Apart from binding to the dopamine transporter (DAT), [(123)I]FP-CIT shows moderate affinity for the serotonin transporter (SERT), allowing imaging of both monoamine transporters in a single imaging session in different brain areas. The aim of this study was to systematically evaluate extrastriatal binding (predominantly due to SERT) and its age and gender dependencies in a large cohort of healthy controls.METHODS: SPECT data from 103 healthy controls with well-defined criteria of normality acquired at 13 different imaging centres were analysed for extrastriatal binding using volumes of interest analysis for the thalamus and the pons. Data were examined for gender and age effects as well as for potential influence of striatal DAT radiotracer binding.RESULTS: Thalamic binding was significantly higher than pons binding. Partial correlations showed an influence of putaminal DAT binding on measured binding in the thalamus but not on the pons. Data showed high interindividual variation in extrastriatal binding. Significant gender effects with 31 % higher binding in women than in men were observed in the thalamus, but not in the pons. An age dependency with a decline per decade (±standard error) of 8.2 ± 1.3 % for the thalamus and 6.8 ± 2.9 % for the pons was shown.CONCLUSION: The potential to evaluate extrastriatal predominant SERT binding in addition to the striatal DAT in a single imaging session was shown using a large database of [(123)I]FP-CIT scans in healthy controls. For both the thalamus and the pons, an age-related decline in radiotracer binding was observed. Gender effects were demonstrated for binding in the thalamus only. As a potential clinical application, the data could be used as a reference to estimate SERT occupancy in addition to nigrostriatal integrity when using [(123)I]FP-CIT for DAT imaging in patients treated with selective serotonin reuptake inhibitors.

AB - PURPOSE: Apart from binding to the dopamine transporter (DAT), [(123)I]FP-CIT shows moderate affinity for the serotonin transporter (SERT), allowing imaging of both monoamine transporters in a single imaging session in different brain areas. The aim of this study was to systematically evaluate extrastriatal binding (predominantly due to SERT) and its age and gender dependencies in a large cohort of healthy controls.METHODS: SPECT data from 103 healthy controls with well-defined criteria of normality acquired at 13 different imaging centres were analysed for extrastriatal binding using volumes of interest analysis for the thalamus and the pons. Data were examined for gender and age effects as well as for potential influence of striatal DAT radiotracer binding.RESULTS: Thalamic binding was significantly higher than pons binding. Partial correlations showed an influence of putaminal DAT binding on measured binding in the thalamus but not on the pons. Data showed high interindividual variation in extrastriatal binding. Significant gender effects with 31 % higher binding in women than in men were observed in the thalamus, but not in the pons. An age dependency with a decline per decade (±standard error) of 8.2 ± 1.3 % for the thalamus and 6.8 ± 2.9 % for the pons was shown.CONCLUSION: The potential to evaluate extrastriatal predominant SERT binding in addition to the striatal DAT in a single imaging session was shown using a large database of [(123)I]FP-CIT scans in healthy controls. For both the thalamus and the pons, an age-related decline in radiotracer binding was observed. Gender effects were demonstrated for binding in the thalamus only. As a potential clinical application, the data could be used as a reference to estimate SERT occupancy in addition to nigrostriatal integrity when using [(123)I]FP-CIT for DAT imaging in patients treated with selective serotonin reuptake inhibitors.

U2 - 10.1007/s00259-014-2785-8

DO - 10.1007/s00259-014-2785-8

M3 - Journal article

C2 - 24806112

VL - 41

SP - 1938

EP - 1946

JO - European Journal Of Nuclear Medicine

JF - European Journal Of Nuclear Medicine

SN - 1619-7070

IS - 10

ER -

Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls

Abstrakt

Adgang til dokumentet

Fingeraftryk

Citationsformater