Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection

Michael F Ofori, Trine Staalsoe, Victoria Bam, Maja Lundquist, Kim P David, Edmund N L Browne, Bartholomew D Akanmori, Lars Hviid

Abstract

Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSA(PAM)) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSA(PAM), making them a convenient source of VSA(PAM) expressors for PAM vaccine research.

OriginalsprogEngelsk
TidsskriftInfection and Immunity
Vol/bind71
Udgave nummer3
Sider (fra-til)1584-6
Antal sider3
ISSN0019-9567
DOI
StatusUdgivet - mar. 2003
Udgivet eksterntJa

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