Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Expression of the glycolipid globotriaosylceramide (Gb3) in testicular carcinoma in situ

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Lymphomas of the head and neck region: an update

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Prognostic significance of 1p36 locus deletion in adenoid cystic carcinoma of the salivary glands

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Reduced H3K27me3 expression in radiation-associated angiosarcoma of the breast

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. CENTRAL PRECOCIOUS PUBERTY IN TWO BOYS WITH PRADER-WILLI SYNDROME ON GROWTH HORMONE TREATMENT

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. High maternal age at first and subsequent child births in Denmark in the mid-1800s-Letter to the editor

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Characterisation and localisation of the endocannabinoid system components in the adult human testis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Changes in the cell membrane glycolipid composition and metabolism are frequently associated with carcinogenesis. The accumulation of globo-series glycolipids is the most notable change of the germ cell glycolipid composition observed in testicular tumours. In this study, the expression of the globo-series core-structure, globotriaosylceramide (Gb3) was investigated in the preinvasive stage of testicular germ cell tumours, carcinoma in situ (CIS). Seventeen tissue specimens with CIS and 12 samples of overt testicular tumours were immunostained with anti-Gb3 monoclonal antibody 38-13. The accumulation of Gb3 was detected in 12 CIS samples (70.6%) and in 8 invasive tumour samples (66.7%), including seminoma, non-seminoma and a combined germ cell tumour. Our findings indicate that the composition of glycolipids shift at the common preinvasive stage of testicular germ cell tumours and confirm that Gb3 is a tumour-associated antigen of testicular germ cell neoplasia.

OriginalsprogEngelsk
TidsskriftVirchows Archiv : an international journal of pathology
Vol/bind426
Udgave nummer4
Sider (fra-til)369-74
Antal sider6
ISSN0945-6317
StatusUdgivet - 1995

ID: 44857312