TY - JOUR
T1 - Expression of PIK3CA, PTEN mRNA and PIK3CA mutations in primary breast cancer
T2 - association with lymph node metastases
AU - Palimaru, Irina
AU - Brügmann, Anja Høegh
AU - Wium-Andersen, Marie Kim
AU - Nexo, Ebba
AU - Sorensen, Boe Sandahl
PY - 2013
Y1 - 2013
N2 - High activity of the intracellular phosphatidylinositol-3 kinase (PI3K) pathway is common in breast cancer. Here, we explore differences in expression of important PI3K pathway regulators: the activator, phosphatidylinositol-3-kinase catalytic subunit alpha (PIK3CA), and the tumour suppressor, phosphatase and tensin homolog (PTEN), in breast carcinoma tissue and normal breast tissue. Furthermore, we examine whether expression of PIK3CA and PTEN mRNA and occurrence of PIK3CA mutations are associated with lymph node metastases in patients with primary breast cancer.
AB - High activity of the intracellular phosphatidylinositol-3 kinase (PI3K) pathway is common in breast cancer. Here, we explore differences in expression of important PI3K pathway regulators: the activator, phosphatidylinositol-3-kinase catalytic subunit alpha (PIK3CA), and the tumour suppressor, phosphatase and tensin homolog (PTEN), in breast carcinoma tissue and normal breast tissue. Furthermore, we examine whether expression of PIK3CA and PTEN mRNA and occurrence of PIK3CA mutations are associated with lymph node metastases in patients with primary breast cancer.
U2 - 10.1186/2193-1801-2-464
DO - 10.1186/2193-1801-2-464
M3 - Journal article
C2 - 24083111
SN - 2193-1801
VL - 2
SP - 464
JO - SpringerPlus
JF - SpringerPlus
ER -