Expression of ICAM-1 in colon epithelial cells: an ultrastructural study performed on in vivo and in vitro models

Ben Vainer; Susanne Sørensen; Jakob Seidelin; Ole Haagen Nielsen; Thomas Horn

doi:10.1007/s00428-003-0900-5

Expression of ICAM-1 in colon epithelial cells: an ultrastructural study performed on in vivo and in vitro models

Ben Vainer, Susanne Sørensen, Jakob Seidelin, Ole Haagen Nielsen, Thomas Horn

13 Citationer (Scopus)

Abstract

Studies have suggested that in ulcerative colitis (UC), intercellular adhesion molecule-1 (ICAM-1) is involved in migration of leukocytes toward the colonic epithelium. A suitable in vitro model of chronic colonic inflammation does not exist, and the role of the epithelium is based on monolayers of cancer cells. Conflicting results exist on epithelial ICAM-1 expression, and the aim of this study was to compare the expression in various models of colonic epithelium.

Originalsprog	Engelsk
Tidsskrift	Virchows Archiv
Vol/bind	443
Udgave nummer	6
Sider (fra-til)	774-81
Antal sider	8
ISSN	0945-6317
DOI	https://doi.org/10.1007/s00428-003-0900-5
Status	Udgivet - 2003

Adgang til dokumentet

10.1007/s00428-003-0900-5

Citationsformater

@article{9c01708d1a7a4e6695509e5f794090e1,

title = "Expression of ICAM-1 in colon epithelial cells: an ultrastructural study performed on in vivo and in vitro models",

abstract = "Studies have suggested that in ulcerative colitis (UC), intercellular adhesion molecule-1 (ICAM-1) is involved in migration of leukocytes toward the colonic epithelium. A suitable in vitro model of chronic colonic inflammation does not exist, and the role of the epithelium is based on monolayers of cancer cells. Conflicting results exist on epithelial ICAM-1 expression, and the aim of this study was to compare the expression in various models of colonic epithelium.",

keywords = "Adult, Colitis, Ulcerative, Colon, Colonic Neoplasms, Female, HT29 Cells, Humans, Intercellular Adhesion Molecule-1, Interferon-gamma, Intestinal Mucosa, Male, Microscopy, Electron, Tumor Necrosis Factor-alpha",

author = "Ben Vainer and Susanne S{\o}rensen and Jakob Seidelin and Nielsen, {Ole Haagen} and Thomas Horn",

year = "2003",

doi = "10.1007/s00428-003-0900-5",

language = "English",

volume = "443",

pages = "774--81",

journal = "Virchows Archiv",

issn = "0945-6317",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "6",

}

TY - JOUR

T1 - Expression of ICAM-1 in colon epithelial cells

T2 - an ultrastructural study performed on in vivo and in vitro models

AU - Vainer, Ben

AU - Sørensen, Susanne

AU - Seidelin, Jakob

AU - Nielsen, Ole Haagen

AU - Horn, Thomas

PY - 2003

Y1 - 2003

N2 - Studies have suggested that in ulcerative colitis (UC), intercellular adhesion molecule-1 (ICAM-1) is involved in migration of leukocytes toward the colonic epithelium. A suitable in vitro model of chronic colonic inflammation does not exist, and the role of the epithelium is based on monolayers of cancer cells. Conflicting results exist on epithelial ICAM-1 expression, and the aim of this study was to compare the expression in various models of colonic epithelium.

AB - Studies have suggested that in ulcerative colitis (UC), intercellular adhesion molecule-1 (ICAM-1) is involved in migration of leukocytes toward the colonic epithelium. A suitable in vitro model of chronic colonic inflammation does not exist, and the role of the epithelium is based on monolayers of cancer cells. Conflicting results exist on epithelial ICAM-1 expression, and the aim of this study was to compare the expression in various models of colonic epithelium.

KW - Adult

KW - Colitis, Ulcerative

KW - Colon

KW - Colonic Neoplasms

KW - Female

KW - HT29 Cells

KW - Humans

KW - Intercellular Adhesion Molecule-1

KW - Interferon-gamma

KW - Intestinal Mucosa

KW - Male

KW - Microscopy, Electron

KW - Tumor Necrosis Factor-alpha

U2 - 10.1007/s00428-003-0900-5

DO - 10.1007/s00428-003-0900-5

M3 - Journal article

C2 - 14564519

SN - 0945-6317

VL - 443

SP - 774

EP - 781

JO - Virchows Archiv

JF - Virchows Archiv

IS - 6

ER -

Expression of ICAM-1 in colon epithelial cells: an ultrastructural study performed on in vivo and in vitro models

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater