Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV

Birgitte Lindegaard; Thine  Hvid; Thomas Grøndahl; Christian Frøsig; Jan Gerstoft; Pernille Hojman; Bente Klarlund Pedersen

doi:10.1371/journal.pone.0055632

Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV

Birgitte Lindegaard, Thine Hvid, Thomas Grøndahl, Christian Frøsig, Jan Gerstoft, Pernille Hojman, Bente Klarlund Pedersen

25 Citationer (Scopus)

Abstract

Fibroblast growth factor (FGF)-21 is a novel regulator of glucose and lipid metabolism. Recently, increased FGF-21 mRNA expression in muscle was found in patients with type 2 diabetes, but the role for FGF-21 in muscle is not well understood. Patients with HIV-infection and lipodystrophy are characterised by various degree of lipid-driven insulin resistance. We hypothesized that muscle FGF-21 mRNA would be altered in HIV patients with lipodystrophy.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	8
Udgave nummer	3
Sider (fra-til)	e55632
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0055632
Status	Udgivet - 2013

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title = "Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV",

abstract = "Fibroblast growth factor (FGF)-21 is a novel regulator of glucose and lipid metabolism. Recently, increased FGF-21 mRNA expression in muscle was found in patients with type 2 diabetes, but the role for FGF-21 in muscle is not well understood. Patients with HIV-infection and lipodystrophy are characterised by various degree of lipid-driven insulin resistance. We hypothesized that muscle FGF-21 mRNA would be altered in HIV patients with lipodystrophy.",

keywords = "Adult, Case-Control Studies, Female, Fibroblast Growth Factors, HIV Infections, Humans, Insulin Resistance, Lipodystrophy, Male, Middle Aged, Muscle, Skeletal",

author = "Birgitte Lindegaard and Thine Hvid and Thomas Gr{\o}ndahl and Christian Fr{\o}sig and Jan Gerstoft and Pernille Hojman and Pedersen, \{Bente Klarlund\}",

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T1 - Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV

AU - Lindegaard, Birgitte

AU - Hvid, Thine

AU - Grøndahl, Thomas

AU - Frøsig, Christian

AU - Gerstoft, Jan

AU - Hojman, Pernille

AU - Pedersen, Bente Klarlund

PY - 2013

Y1 - 2013

N2 - Fibroblast growth factor (FGF)-21 is a novel regulator of glucose and lipid metabolism. Recently, increased FGF-21 mRNA expression in muscle was found in patients with type 2 diabetes, but the role for FGF-21 in muscle is not well understood. Patients with HIV-infection and lipodystrophy are characterised by various degree of lipid-driven insulin resistance. We hypothesized that muscle FGF-21 mRNA would be altered in HIV patients with lipodystrophy.

AB - Fibroblast growth factor (FGF)-21 is a novel regulator of glucose and lipid metabolism. Recently, increased FGF-21 mRNA expression in muscle was found in patients with type 2 diabetes, but the role for FGF-21 in muscle is not well understood. Patients with HIV-infection and lipodystrophy are characterised by various degree of lipid-driven insulin resistance. We hypothesized that muscle FGF-21 mRNA would be altered in HIV patients with lipodystrophy.

KW - Adult

KW - Case-Control Studies

KW - Female

KW - Fibroblast Growth Factors

KW - HIV Infections

KW - Humans

KW - Insulin Resistance

KW - Lipodystrophy

KW - Male

KW - Middle Aged

KW - Muscle, Skeletal

UR - https://www.scopus.com/pages/publications/84875327535

U2 - 10.1371/journal.pone.0055632

DO - 10.1371/journal.pone.0055632

M3 - Journal article

C2 - 23533568

SN - 1932-6203

VL - 8

SP - e55632

JO - P L o S One

JF - P L o S One

IS - 3

ER -

Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV

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