Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV

Birgitte Lindegaard, Thine Hvid, Thomas Grøndahl, Christian Frøsig, Jan Gerstoft, Pernille Hojman, Bente Klarlund Pedersen

    24 Citationer (Scopus)

    Abstract

    Fibroblast growth factor (FGF)-21 is a novel regulator of glucose and lipid metabolism. Recently, increased FGF-21 mRNA expression in muscle was found in patients with type 2 diabetes, but the role for FGF-21 in muscle is not well understood. Patients with HIV-infection and lipodystrophy are characterised by various degree of lipid-driven insulin resistance. We hypothesized that muscle FGF-21 mRNA would be altered in HIV patients with lipodystrophy.
    OriginalsprogEngelsk
    TidsskriftP L o S One
    Vol/bind8
    Udgave nummer3
    Sider (fra-til)e55632
    ISSN1932-6203
    DOI
    StatusUdgivet - 2013

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