Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Exposure to selective serotonin reuptake inhibitors in utero and early elementary school outcomes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Hippocampal Volume and Memory Impairment after Electroconvulsive Therapy in Patients with Depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The Validity of Child and Adolescent Depression Diagnoses in the Danish Psychiatric Central Research Register

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Familial risk and heritability of depression by age at first diagnosis in Danish twins

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. High suicide rates during psychiatric inpatient stay and shortly after discharge

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Oral contraceptives and the serotonin 4 receptor: a molecular brain imaging study in healthy women

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Prognosis of myocardial infarction-related cardiogenic shock according to preadmission out-of-hospital cardiac arrest

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Socioeconomic disparities in prehospital factors and survival after out-of-hospital cardiac arrest

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. "The Timing of Venous Thromboembolism in Ovarian Cancer patients. A Nationwide Danish Cohort Study"

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Cardiovascular comorbidities as predictors for severe COVID-19 infection or death

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: Data on special education in offspring exposed to selective serotonin reuptake inhibitors (SSRIs) in utero are lacking. We examined associations of in utero SSRI exposure with special education needs and delayed elementary school start.

METHODS: A population-based case-cohort study using Danish nationwide birth and prescription registry data from 2005 to 2008. Follow-up ends during 2011-2015 to capture special education needs during and delayed entry to the first elementary school year. Cases were in utero SSRI-exposed offspring. Cohort-controls were SSRI-unexposed offspring of mothers previously on SSRIs. We reported odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for relevant potential confounders.

RESULTS: Of 117 475 first-incident non-multiple pregnancy births, 3314 were SSRI-exposed, and 3536 were unexposed. Among SSRI-exposed offspring, 3.2% (n = 98) had special school needs vs. 2.4% (n = 77) in unexposed offspring, P-value=0.048. Correspondingly, 12.3% (n = 383) among SSRI-exposed children had delayed school entry vs. 9.4% (n = 308) in unexposed offspring, P-value < 0.001. Adjusted OR for the association with special school needs was 1.12 (95% CI 0.82-1.55; P-value = 0.48) and 1.38 (95% CI 0.90-2.13; P-value = 0.14) for exposure in all three trimesters. The corresponding adjusted ORs for delayed school entry were 1.17 (95% CI 0.99-1.38; P-value = 0.073) and 1.40 (95% CI 1.11-1.76; P-value = 0.004).

CONCLUSION: In utero SSRI exposure in all three trimesters was associated with delayed elementary school start but not special education needs.

OriginalsprogEngelsk
TidsskriftActa Psychiatrica Scandinavica
Vol/bind137
Udgave nummer6
Sider (fra-til)481-490
Antal sider10
ISSN0001-690X
DOI
StatusUdgivet - jun. 2018

ID: 55616403