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Exposure assessment for a nested case-control study of lung cancer among European asphalt workers

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Michela Agostini
  • Gilles Ferro
  • Ann Olsson
  • Igor Burstyn
  • Frank De Vocht
  • Johnni Hansen
  • Christina Funch Lassen
  • Christoffer Johansen
  • Kristina Kjaerheim
  • Sverre Langard
  • Isabelle Stucker
  • Wolfgang Ahrens
  • Thomas Behrens
  • Marja-Liisa Lindbohm
  • Pirjo Heikkilä
  • Dick Heederik
  • Lützen Portengen
  • Judith Shaham
  • Paolo Boffetta
  • Hans Kromhout
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OBJECTIVE: Development of a method for retrospective assessment of exposure to bitumen fume, bitumen condensate, organic vapour, polycyclic aromatic hydrocarbons, and co-exposures to known or suspected lung carcinogens for a nested case-control study of lung cancer mortality among European asphalt workers.

METHODS: Company questionnaires and structured questionnaires used in interviews and industry-specific job-exposure matrices (JEMs) were elaborated and applied. Three sources of information were eventually used for exposure assessment and assignment: (i) data obtained in cohort phase, (ii) data from living subjects, next-of-kin, and fellow-workers questionnaires, and (iii) JEMs for bitumen exposure by inhalation and via skin and co-exposures to known or suspected lung carcinogens within and outside cohort companies. Inhalation and dermal exposure estimates for bitumen were adjusted for time trends, time spent in a job, and other determinants of exposure (e.g. oil gravel paving). Clothing patterns, personal protective devices, and personal hygiene were taken into consideration while estimating dermal exposure.

RESULTS: Occupational exposures could be assessed for 433 cases and 1253 controls for relevant time periods. Only 43% of work histories were spent inside original asphalt and construction companies. A total of 95.8% of job periods in cohort companies could be coded at a more detailed level. Imputation of work time and 'hygienic behaviour' multipliers was needed for <10% of work history years. Overall, downward trends in exposure were present and differences existed between countries and companies. As expected, correlations were strongest (r > 0.7) among bitumen-related agents, while correlations between coal tar, bitumen-related agents, and established lung carcinogens were weaker (r < 0.4).

CONCLUSIONS: A systematic and detailed approach was developed to estimate inhalation and dermal exposure for a nested case-control study among asphalt workers.

OriginalsprogEngelsk
TidsskriftThe Annals of occupational hygiene
Vol/bind54
Udgave nummer7
Sider (fra-til)813-23
Antal sider11
ISSN0003-4878
DOI
StatusUdgivet - okt. 2010

ID: 57390460