Exploring soluble urokinase plasminogen activator receptor and its relationship with arterial stiffness in a bi-ethnic population: the SAfrEIC-study

Aletta E Schutte; Anélda Myburgh; Michael H Olsen; Jesper Eugen-Olsen; Rudolph Schutte

doi:10.1016/j.thromres.2011.10.034

Exploring soluble urokinase plasminogen activator receptor and its relationship with arterial stiffness in a bi-ethnic population: the SAfrEIC-study

Aletta E Schutte, Anélda Myburgh, Michael H Olsen, Jesper Eugen-Olsen, Rudolph Schutte

19 Citationer (Scopus)

Abstract

INTRODUCTION: Elevated soluble urokinase-type plasminogen activator receptor (suPAR) indicates an inflammatory state caused by conditions such as HIV and cancer. Recently suPAR was identified as an indicator of cardiovascular disease (CVD). CVD is highly prevalent in black South Africans, but the potential role of suPAR is unknown. We investigated suPAR as a possible marker of arterial stiffness in Africans and Caucasians. METHODS: This study involved 207 Africans and 314 Caucasians (aged 20-70yrs). C-reactive protein (CRP) and suPAR were determined in fasting blood samples. We measured blood pressure, pulse wave velocity (PWV) and Windkessel arterial compliance (Cwk). RESULTS: Africans displayed higher suPAR, CRP, PWV and lower Cwk (p

Originalsprog	Engelsk
Tidsskrift	Thrombosis Research
Vol/bind	130
Udgave nummer	2
Sider (fra-til)	273-277
Antal sider	5
ISSN	0049-3848
DOI	https://doi.org/10.1016/j.thromres.2011.10.034
Status	Udgivet - 2012

Adgang til dokumentet

10.1016/j.thromres.2011.10.034

Citationsformater

@article{86d7014b249e4c4f9824c0866a5cc6e5,

title = "Exploring soluble urokinase plasminogen activator receptor and its relationship with arterial stiffness in a bi-ethnic population: the SAfrEIC-study",

abstract = "INTRODUCTION: Elevated soluble urokinase-type plasminogen activator receptor (suPAR) indicates an inflammatory state caused by conditions such as HIV and cancer. Recently suPAR was identified as an indicator of cardiovascular disease (CVD). CVD is highly prevalent in black South Africans, but the potential role of suPAR is unknown. We investigated suPAR as a possible marker of arterial stiffness in Africans and Caucasians. METHODS: This study involved 207 Africans and 314 Caucasians (aged 20-70yrs). C-reactive protein (CRP) and suPAR were determined in fasting blood samples. We measured blood pressure, pulse wave velocity (PWV) and Windkessel arterial compliance (Cwk). RESULTS: Africans displayed higher suPAR, CRP, PWV and lower Cwk (p",

author = "Schutte, {Aletta E} and An{\'e}lda Myburgh and Olsen, {Michael H} and Jesper Eugen-Olsen and Rudolph Schutte",

year = "2012",

doi = "10.1016/j.thromres.2011.10.034",

language = "English",

volume = "130",

pages = "273--277",

journal = "Thrombosis Research",

issn = "0049-3848",

publisher = "Pergamon",

number = "2",

}

TY - JOUR

T1 - Exploring soluble urokinase plasminogen activator receptor and its relationship with arterial stiffness in a bi-ethnic population: the SAfrEIC-study

AU - Schutte, Aletta E

AU - Myburgh, Anélda

AU - Olsen, Michael H

AU - Eugen-Olsen, Jesper

AU - Schutte, Rudolph

PY - 2012

Y1 - 2012

N2 - INTRODUCTION: Elevated soluble urokinase-type plasminogen activator receptor (suPAR) indicates an inflammatory state caused by conditions such as HIV and cancer. Recently suPAR was identified as an indicator of cardiovascular disease (CVD). CVD is highly prevalent in black South Africans, but the potential role of suPAR is unknown. We investigated suPAR as a possible marker of arterial stiffness in Africans and Caucasians. METHODS: This study involved 207 Africans and 314 Caucasians (aged 20-70yrs). C-reactive protein (CRP) and suPAR were determined in fasting blood samples. We measured blood pressure, pulse wave velocity (PWV) and Windkessel arterial compliance (Cwk). RESULTS: Africans displayed higher suPAR, CRP, PWV and lower Cwk (p

AB - INTRODUCTION: Elevated soluble urokinase-type plasminogen activator receptor (suPAR) indicates an inflammatory state caused by conditions such as HIV and cancer. Recently suPAR was identified as an indicator of cardiovascular disease (CVD). CVD is highly prevalent in black South Africans, but the potential role of suPAR is unknown. We investigated suPAR as a possible marker of arterial stiffness in Africans and Caucasians. METHODS: This study involved 207 Africans and 314 Caucasians (aged 20-70yrs). C-reactive protein (CRP) and suPAR were determined in fasting blood samples. We measured blood pressure, pulse wave velocity (PWV) and Windkessel arterial compliance (Cwk). RESULTS: Africans displayed higher suPAR, CRP, PWV and lower Cwk (p

U2 - 10.1016/j.thromres.2011.10.034

DO - 10.1016/j.thromres.2011.10.034

M3 - Journal article

C2 - 22113150

SN - 0049-3848

VL - 130

SP - 273

EP - 277

JO - Thrombosis Research

JF - Thrombosis Research

IS - 2

ER -

Exploring soluble urokinase plasminogen activator receptor and its relationship with arterial stiffness in a bi-ethnic population: the SAfrEIC-study

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater