Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{c1a8763cf8c240c4b814541fc4ed87a7,
title = "Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling",
abstract = "BACKGROUND: Voluntary activation deficit of the quadriceps muscle group is a common symptom in populations with knee joint injury. Musculoskeletal modeling and simulations can improve our understanding of pathological conditions; however, they are mathematically complex which can limit their clinical application. A practical subject-specific modeling framework is introduced to evaluate knee extensor inhibition and muscle force contributions to isometric knee joint torques in healthy adults with and without experimentally induced quadriceps muscle pain.METHODS: A randomized cross-over placebo controlled study design was used. Subject-specific maximum knee joint extension torque and quadriceps electromyographic data from 13 uninjured young adults were combined in a modeling framework to determine optimal muscle strength scaling parameters and ideal torque. Strength deficit ratios (experimental torque/ideal torque) and individual muscle contribution to experimental torque was computed before and after intramuscular hypertonic (pain inducing) and isotonic (sham) saline was injected to the vastus medialis.FINDINGS: Decreased experimental knee extension torque (-8%) and vastus medialis electromyography (-26%) amplitude pre- to post- hypertonic injection was observed. Correspondingly, significant decreases in the knee extensor strength deficit ratio (-18%) and percent contribution of vastus medialis to experimental torque (-24%) was observed pre- to post- hypertonic injection. No differences were observed with isotonic injections, confirming the validity of the model.INTERPRETATION: Our practical method to estimate strength ratios can be easily implemented within a musculoskeletal modeling framework to improve the validity of model estimates. This, in turn, can increase our understanding of the relationship between neuromuscular deficits and functional outcomes in patient populations.",
author = "Flaxman, {Teresa E} and Shourijeh, {Mohammad S} and Tine Alkj{\ae}r and Krogsgaard, {Michael R} and Simonsen, {Erik B} and Heather Bigham and Benoit, {Daniel L}",
note = "Copyright {\textcopyright} 2019 Elsevier Ltd. All rights reserved.",
year = "2019",
month = jul,
doi = "10.1016/j.clinbiomech.2019.04.005",
language = "English",
volume = "67",
pages = "27--33",
journal = "Clinical Biomechanics",
issn = "0268-0033",
publisher = "Pergamon",

}

RIS

TY - JOUR

T1 - Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling

AU - Flaxman, Teresa E

AU - Shourijeh, Mohammad S

AU - Alkjær, Tine

AU - Krogsgaard, Michael R

AU - Simonsen, Erik B

AU - Bigham, Heather

AU - Benoit, Daniel L

N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.

PY - 2019/7

Y1 - 2019/7

N2 - BACKGROUND: Voluntary activation deficit of the quadriceps muscle group is a common symptom in populations with knee joint injury. Musculoskeletal modeling and simulations can improve our understanding of pathological conditions; however, they are mathematically complex which can limit their clinical application. A practical subject-specific modeling framework is introduced to evaluate knee extensor inhibition and muscle force contributions to isometric knee joint torques in healthy adults with and without experimentally induced quadriceps muscle pain.METHODS: A randomized cross-over placebo controlled study design was used. Subject-specific maximum knee joint extension torque and quadriceps electromyographic data from 13 uninjured young adults were combined in a modeling framework to determine optimal muscle strength scaling parameters and ideal torque. Strength deficit ratios (experimental torque/ideal torque) and individual muscle contribution to experimental torque was computed before and after intramuscular hypertonic (pain inducing) and isotonic (sham) saline was injected to the vastus medialis.FINDINGS: Decreased experimental knee extension torque (-8%) and vastus medialis electromyography (-26%) amplitude pre- to post- hypertonic injection was observed. Correspondingly, significant decreases in the knee extensor strength deficit ratio (-18%) and percent contribution of vastus medialis to experimental torque (-24%) was observed pre- to post- hypertonic injection. No differences were observed with isotonic injections, confirming the validity of the model.INTERPRETATION: Our practical method to estimate strength ratios can be easily implemented within a musculoskeletal modeling framework to improve the validity of model estimates. This, in turn, can increase our understanding of the relationship between neuromuscular deficits and functional outcomes in patient populations.

AB - BACKGROUND: Voluntary activation deficit of the quadriceps muscle group is a common symptom in populations with knee joint injury. Musculoskeletal modeling and simulations can improve our understanding of pathological conditions; however, they are mathematically complex which can limit their clinical application. A practical subject-specific modeling framework is introduced to evaluate knee extensor inhibition and muscle force contributions to isometric knee joint torques in healthy adults with and without experimentally induced quadriceps muscle pain.METHODS: A randomized cross-over placebo controlled study design was used. Subject-specific maximum knee joint extension torque and quadriceps electromyographic data from 13 uninjured young adults were combined in a modeling framework to determine optimal muscle strength scaling parameters and ideal torque. Strength deficit ratios (experimental torque/ideal torque) and individual muscle contribution to experimental torque was computed before and after intramuscular hypertonic (pain inducing) and isotonic (sham) saline was injected to the vastus medialis.FINDINGS: Decreased experimental knee extension torque (-8%) and vastus medialis electromyography (-26%) amplitude pre- to post- hypertonic injection was observed. Correspondingly, significant decreases in the knee extensor strength deficit ratio (-18%) and percent contribution of vastus medialis to experimental torque (-24%) was observed pre- to post- hypertonic injection. No differences were observed with isotonic injections, confirming the validity of the model.INTERPRETATION: Our practical method to estimate strength ratios can be easily implemented within a musculoskeletal modeling framework to improve the validity of model estimates. This, in turn, can increase our understanding of the relationship between neuromuscular deficits and functional outcomes in patient populations.

U2 - 10.1016/j.clinbiomech.2019.04.005

DO - 10.1016/j.clinbiomech.2019.04.005

M3 - Journal article

C2 - 31071535

VL - 67

SP - 27

EP - 33

JO - Clinical Biomechanics

JF - Clinical Biomechanics

SN - 0268-0033

ER -

ID: 58972865