Experience in qualitative and quantitative FDG PET in follow-up of patients with suspected recurrence from head and neck cancer

M Lapela, A Eigtved, S Jyrkkiö, R Grénman, T Kurki, P Lindholm, J Nuutinen, E Sutinen, O Solin, I Bjornskov, Poul Holmer Bretlau, L Friberg, S Holm, M Jensen, H Sand Hansen, H Minn

109 Citationer (Scopus)

Abstract

We evaluated positron emission tomography (PET) with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) in the detection of recurrent head and neck cancer, and compared visual and quantitative interpretation of PET images for their accuracy in the identification of tumour recurrence. Sixty-two FDG PET studies were performed in 56 patients having a total of 81 lesions, which were clinically suspected for recurrent carcinoma of the head and neck. The PET images were interpreted visually, and tracer uptake was quantitated as the standardised uptake value adjusted to body weight (SUV). Sensitivity of visual interpretation of the PET images for the presence of malignancy ranged from 84 to 95%, and specificity from 84 to 93%, respectively, depending on the selected scheme for grading of the lesions. Malignant lesions accumulated significantly more FDG than the benign ones (the median SUVs were 6.8 and 3.3, respectively, P
OriginalsprogEngelsk
TidsskriftEuropean Journal of Cancer
Vol/bind36
Udgave nummer7
Sider (fra-til)858-67
Antal sider10
ISSN0959-8049
StatusUdgivet - maj 2000

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