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Expanding our understanding of ovarian cancer risk: the role of incomplete pregnancies

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Harvard

Lee, AW, Rosenzweig, S, Wiensch, A, Ramus, SJ, Menon, U, Gentry-Maharaj, A, Ziogas, A, Anton-Culver, H, Whittemore, AS, Sieh, W, Rothstein, JH, McGuire, V, Wentzensen, N, Bandera, EV, Qin, B, Terry, KL, Cramer, DW, Titus, L, Schildkraut, JM, Berchuck, A, Goode, EL, Kjaer, SK, Jensen, A, Jordan, SJ, Ness, RB, Modugno, F, Moysich, K, Thompson, PJ, Goodman, MT, Carney, ME, Chang-Claude, J, Rossing, MA, Harris, HR, Doherty, JA, Risch, HA, Khoja, L, Alimujiang, A, Phung, MT, Brieger, K, Mukherjee, B, Pharoah, PDP, Wu, AH, Pike, MC, Webb, PM, Pearce, CL & Australian Ovarian Cancer Study Group 2021, 'Expanding our understanding of ovarian cancer risk: the role of incomplete pregnancies', National Cancer Institute. Journal (Online), bind 113, nr. 3, s. 301-308. https://doi.org/10.1093/jnci/djaa099

APA

Lee, A. W., Rosenzweig, S., Wiensch, A., Ramus, S. J., Menon, U., Gentry-Maharaj, A., Ziogas, A., Anton-Culver, H., Whittemore, A. S., Sieh, W., Rothstein, J. H., McGuire, V., Wentzensen, N., Bandera, E. V., Qin, B., Terry, K. L., Cramer, D. W., Titus, L., Schildkraut, J. M., ... Australian Ovarian Cancer Study Group (2021). Expanding our understanding of ovarian cancer risk: the role of incomplete pregnancies. National Cancer Institute. Journal (Online), 113(3), 301-308. https://doi.org/10.1093/jnci/djaa099

CBE

Lee AW, Rosenzweig S, Wiensch A, Ramus SJ, Menon U, Gentry-Maharaj A, Ziogas A, Anton-Culver H, Whittemore AS, Sieh W, Rothstein JH, McGuire V, Wentzensen N, Bandera EV, Qin B, Terry KL, Cramer DW, Titus L, Schildkraut JM, Berchuck A, Goode EL, Kjaer SK, Jensen A, Jordan SJ, Ness RB, Modugno F, Moysich K, Thompson PJ, Goodman MT, Carney ME, Chang-Claude J, Rossing MA, Harris HR, Doherty JA, Risch HA, Khoja L, Alimujiang A, Phung MT, Brieger K, Mukherjee B, Pharoah PDP, Wu AH, Pike MC, Webb PM, Pearce CL, Australian Ovarian Cancer Study Group. 2021. Expanding our understanding of ovarian cancer risk: the role of incomplete pregnancies. National Cancer Institute. Journal (Online). 113(3):301-308. https://doi.org/10.1093/jnci/djaa099

MLA

Vancouver

Author

Lee, Alice W ; Rosenzweig, Stacey ; Wiensch, Ashley ; Ramus, Susan J ; Menon, Usha ; Gentry-Maharaj, Aleksandra ; Ziogas, Argyrios ; Anton-Culver, Hoda ; Whittemore, Alice S ; Sieh, Weiva ; Rothstein, Joseph H ; McGuire, Valerie ; Wentzensen, Nicolas ; Bandera, Elisa V ; Qin, Bo ; Terry, Kathryn L ; Cramer, Daniel W ; Titus, Linda ; Schildkraut, Joellen M ; Berchuck, Andrew ; Goode, Ellen L ; Kjaer, Susanne K ; Jensen, Allan ; Jordan, Susan J ; Ness, Roberta B ; Modugno, Francesmary ; Moysich, Kirsten ; Thompson, Pamela J ; Goodman, Marc T ; Carney, Michael E ; Chang-Claude, Jenny ; Rossing, Mary Anne ; Harris, Holly R ; Doherty, Jennifer Anne ; Risch, Harvey A ; Khoja, Lilah ; Alimujiang, Aliya ; Phung, Minh Tung ; Brieger, Katharine ; Mukherjee, Bhramar ; Pharoah, Paul D P ; Wu, Anna H ; Pike, Malcolm C ; Webb, Penelope M ; Pearce, Celeste Leigh ; Australian Ovarian Cancer Study Group. / Expanding our understanding of ovarian cancer risk : the role of incomplete pregnancies. I: National Cancer Institute. Journal (Online). 2021 ; Bind 113, Nr. 3. s. 301-308.

Bibtex

@article{f626a17ea3f344f58b41a36016b00f6d,
title = "Expanding our understanding of ovarian cancer risk: the role of incomplete pregnancies",
abstract = "BACKGROUND: Parity is associated with decreased risk of invasive ovarian cancer; however, the relationship between incomplete pregnancies and invasive ovarian cancer risk is unclear. This relationship was examined using 15 case-control studies from the Ovarian Cancer Association Consortium (OCAC). Histotype-specific associations, which have not been examined previously with large sample sizes, were also evaluated.METHODS: A pooled analysis of 10 470 invasive epithelial ovarian cancer cases and 16 942 controls was conducted. Odds ratios (ORs) and 95% confidence intervals (CIs) for the association between incomplete pregnancies and invasive epithelial ovarian cancer were estimated using logistic regression. All models were conditioned on OCAC study, race and ethnicity, age, and education level and adjusted for number of complete pregnancies, oral contraceptive use, and history of breastfeeding. The same approach was used for histotype-specific analyses.RESULTS: Ever having an incomplete pregnancy was associated with a 16% reduction in ovarian cancer risk (OR = 0.84, 95% CI = 0.79 to 0.89). There was a trend of decreasing risk with increasing number of incomplete pregnancies (2-sided Ptrend < .001). An inverse association was observed for all major histotypes; it was strongest for clear cell ovarian cancer.CONCLUSIONS: Incomplete pregnancies are associated with a reduced risk of invasive epithelial ovarian cancer. Pregnancy, including incomplete pregnancy, was associated with a greater reduction in risk of clear cell ovarian cancer, but the result was broadly consistent across histotypes. Future work should focus on understanding the mechanisms underlying this reduced risk.",
author = "Lee, {Alice W} and Stacey Rosenzweig and Ashley Wiensch and Ramus, {Susan J} and Usha Menon and Aleksandra Gentry-Maharaj and Argyrios Ziogas and Hoda Anton-Culver and Whittemore, {Alice S} and Weiva Sieh and Rothstein, {Joseph H} and Valerie McGuire and Nicolas Wentzensen and Bandera, {Elisa V} and Bo Qin and Terry, {Kathryn L} and Cramer, {Daniel W} and Linda Titus and Schildkraut, {Joellen M} and Andrew Berchuck and Goode, {Ellen L} and Kjaer, {Susanne K} and Allan Jensen and Jordan, {Susan J} and Ness, {Roberta B} and Francesmary Modugno and Kirsten Moysich and Thompson, {Pamela J} and Goodman, {Marc T} and Carney, {Michael E} and Jenny Chang-Claude and Rossing, {Mary Anne} and Harris, {Holly R} and Doherty, {Jennifer Anne} and Risch, {Harvey A} and Lilah Khoja and Aliya Alimujiang and Phung, {Minh Tung} and Katharine Brieger and Bhramar Mukherjee and Pharoah, {Paul D P} and Wu, {Anna H} and Pike, {Malcolm C} and Webb, {Penelope M} and Pearce, {Celeste Leigh} and {Australian Ovarian Cancer Study Group}",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.",
year = "2021",
month = mar,
day = "1",
doi = "10.1093/jnci/djaa099",
language = "English",
volume = "113",
pages = "301--308",
journal = "National Cancer Institute. Journal (Online)",
issn = "1460-2105",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Expanding our understanding of ovarian cancer risk

T2 - the role of incomplete pregnancies

AU - Lee, Alice W

AU - Rosenzweig, Stacey

AU - Wiensch, Ashley

AU - Ramus, Susan J

AU - Menon, Usha

AU - Gentry-Maharaj, Aleksandra

AU - Ziogas, Argyrios

AU - Anton-Culver, Hoda

AU - Whittemore, Alice S

AU - Sieh, Weiva

AU - Rothstein, Joseph H

AU - McGuire, Valerie

AU - Wentzensen, Nicolas

AU - Bandera, Elisa V

AU - Qin, Bo

AU - Terry, Kathryn L

AU - Cramer, Daniel W

AU - Titus, Linda

AU - Schildkraut, Joellen M

AU - Berchuck, Andrew

AU - Goode, Ellen L

AU - Kjaer, Susanne K

AU - Jensen, Allan

AU - Jordan, Susan J

AU - Ness, Roberta B

AU - Modugno, Francesmary

AU - Moysich, Kirsten

AU - Thompson, Pamela J

AU - Goodman, Marc T

AU - Carney, Michael E

AU - Chang-Claude, Jenny

AU - Rossing, Mary Anne

AU - Harris, Holly R

AU - Doherty, Jennifer Anne

AU - Risch, Harvey A

AU - Khoja, Lilah

AU - Alimujiang, Aliya

AU - Phung, Minh Tung

AU - Brieger, Katharine

AU - Mukherjee, Bhramar

AU - Pharoah, Paul D P

AU - Wu, Anna H

AU - Pike, Malcolm C

AU - Webb, Penelope M

AU - Pearce, Celeste Leigh

AU - Australian Ovarian Cancer Study Group

N1 - © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PY - 2021/3/1

Y1 - 2021/3/1

N2 - BACKGROUND: Parity is associated with decreased risk of invasive ovarian cancer; however, the relationship between incomplete pregnancies and invasive ovarian cancer risk is unclear. This relationship was examined using 15 case-control studies from the Ovarian Cancer Association Consortium (OCAC). Histotype-specific associations, which have not been examined previously with large sample sizes, were also evaluated.METHODS: A pooled analysis of 10 470 invasive epithelial ovarian cancer cases and 16 942 controls was conducted. Odds ratios (ORs) and 95% confidence intervals (CIs) for the association between incomplete pregnancies and invasive epithelial ovarian cancer were estimated using logistic regression. All models were conditioned on OCAC study, race and ethnicity, age, and education level and adjusted for number of complete pregnancies, oral contraceptive use, and history of breastfeeding. The same approach was used for histotype-specific analyses.RESULTS: Ever having an incomplete pregnancy was associated with a 16% reduction in ovarian cancer risk (OR = 0.84, 95% CI = 0.79 to 0.89). There was a trend of decreasing risk with increasing number of incomplete pregnancies (2-sided Ptrend < .001). An inverse association was observed for all major histotypes; it was strongest for clear cell ovarian cancer.CONCLUSIONS: Incomplete pregnancies are associated with a reduced risk of invasive epithelial ovarian cancer. Pregnancy, including incomplete pregnancy, was associated with a greater reduction in risk of clear cell ovarian cancer, but the result was broadly consistent across histotypes. Future work should focus on understanding the mechanisms underlying this reduced risk.

AB - BACKGROUND: Parity is associated with decreased risk of invasive ovarian cancer; however, the relationship between incomplete pregnancies and invasive ovarian cancer risk is unclear. This relationship was examined using 15 case-control studies from the Ovarian Cancer Association Consortium (OCAC). Histotype-specific associations, which have not been examined previously with large sample sizes, were also evaluated.METHODS: A pooled analysis of 10 470 invasive epithelial ovarian cancer cases and 16 942 controls was conducted. Odds ratios (ORs) and 95% confidence intervals (CIs) for the association between incomplete pregnancies and invasive epithelial ovarian cancer were estimated using logistic regression. All models were conditioned on OCAC study, race and ethnicity, age, and education level and adjusted for number of complete pregnancies, oral contraceptive use, and history of breastfeeding. The same approach was used for histotype-specific analyses.RESULTS: Ever having an incomplete pregnancy was associated with a 16% reduction in ovarian cancer risk (OR = 0.84, 95% CI = 0.79 to 0.89). There was a trend of decreasing risk with increasing number of incomplete pregnancies (2-sided Ptrend < .001). An inverse association was observed for all major histotypes; it was strongest for clear cell ovarian cancer.CONCLUSIONS: Incomplete pregnancies are associated with a reduced risk of invasive epithelial ovarian cancer. Pregnancy, including incomplete pregnancy, was associated with a greater reduction in risk of clear cell ovarian cancer, but the result was broadly consistent across histotypes. Future work should focus on understanding the mechanisms underlying this reduced risk.

UR - http://www.scopus.com/inward/record.url?scp=85102658101&partnerID=8YFLogxK

U2 - 10.1093/jnci/djaa099

DO - 10.1093/jnci/djaa099

M3 - Journal article

C2 - 32766851

VL - 113

SP - 301

EP - 308

JO - National Cancer Institute. Journal (Online)

JF - National Cancer Institute. Journal (Online)

SN - 1460-2105

IS - 3

ER -

ID: 61555758