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Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial

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@article{8f754f35000b447aa54d5cfc47ecc420,
title = "Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial",
abstract = "Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade.",
author = "Anne-Sophie Wedell-Neergaard and {Lang Lehrskov}, Louise and Christensen, {Regitse H{\o}jgaard} and Legaard, {Grit Elster} and Emma Dorph and Larsen, {Monica Korsager} and Natja Launbo and Fagerlind, {Sabrina Ravn} and Seide, {Sidsel Kofoed} and Stine Nymand and Maria Ball and Nicole Vinum and Dahl, {Camilla Noerfelt} and Marie Henneberg and Mathias Ried-Larsen and Nybing, {Janus Damm} and Robin Christensen and Rosenmeier, {Jaya Birgitte} and Kristian Karstoft and Pedersen, {Bente Klarlund} and Helga Ellingsgaard and Rikke Krogh-Madsen",
note = "Copyright {\circledC} 2018 Elsevier Inc. All rights reserved.",
year = "2019",
month = "4",
day = "2",
doi = "10.1016/j.cmet.2018.12.007",
language = "English",
volume = "29",
pages = "844--855.e3",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling

T2 - A Randomized Controlled Trial

AU - Wedell-Neergaard, Anne-Sophie

AU - Lang Lehrskov, Louise

AU - Christensen, Regitse Højgaard

AU - Legaard, Grit Elster

AU - Dorph, Emma

AU - Larsen, Monica Korsager

AU - Launbo, Natja

AU - Fagerlind, Sabrina Ravn

AU - Seide, Sidsel Kofoed

AU - Nymand, Stine

AU - Ball, Maria

AU - Vinum, Nicole

AU - Dahl, Camilla Noerfelt

AU - Henneberg, Marie

AU - Ried-Larsen, Mathias

AU - Nybing, Janus Damm

AU - Christensen, Robin

AU - Rosenmeier, Jaya Birgitte

AU - Karstoft, Kristian

AU - Pedersen, Bente Klarlund

AU - Ellingsgaard, Helga

AU - Krogh-Madsen, Rikke

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2019/4/2

Y1 - 2019/4/2

N2 - Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade.

AB - Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade.

UR - http://www.scopus.com/inward/record.url?scp=85060607072&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2018.12.007

DO - 10.1016/j.cmet.2018.12.007

M3 - Journal article

VL - 29

SP - 844-855.e3

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 4

ER -

ID: 56346951