Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Mechanisms Preserving Insulin Action during High Dietary Fat Intake

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Patients with Obesity Caused by Melanocortin-4 Receptor Mutations Can Be Treated with a Glucagon-like Peptide-1 Receptor Agonist

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Maximizing Cellular Adaptation to Endurance Exercise in Skeletal Muscle

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Effects of Dapagliflozin, Metformin or Exercise on Glucose Metabolism in Individuals with Prediabetes: The PRE-D Trial

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  2. Effects of Dapagliflozin, Metformin or Exercise on Markers of Cardiometabolic Risk: The PRE-D Trial

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  3. Effects of Dapagliflozin, Metformin or Exercise on Glycaemic Variability and Mean Glucose Levels in Prediabetes: The PRE-D Trial

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Vis graf over relationer

Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade.

OriginalsprogEngelsk
TidsskriftCell Metabolism
ISSN1550-4131
DOI
StatusE-pub ahead of print - 2019

ID: 56346951