Exercise-induced liver chemokine CXCL-1 expression is linked to muscle-derived interleukin-6 expression

Non-technical summary  Exercise is known to stimulate the production of various exercise factors including the well-described muscle-derived interleukin-6 (IL-6). We show that exercise causes a massive expression of the chemokine CXCL-1 in serum, in skeletal muscle and especially in the liver. Furthermore we find that this exercise-induced liver CXCL-1 expression is regulated by IL-6 and that muscle-derived IL-6 is capable of stimulating liver CXCL-1 expression. Such knowledge of the regulation of exercise factors contributes to the understanding of how the liver and muscle communicate in response to exercise.