TY - JOUR
T1 - Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling
T2 - A Randomized Controlled Trial
AU - Wedell-Neergaard, Anne-Sophie
AU - Lang Lehrskov, Louise
AU - Christensen, Regitse Højgaard
AU - Legaard, Grit Elster
AU - Dorph, Emma
AU - Larsen, Monica Korsager
AU - Launbo, Natja
AU - Fagerlind, Sabrina Ravn
AU - Seide, Sidsel Kofoed
AU - Nymand, Stine
AU - Ball, Maria
AU - Vinum, Nicole
AU - Dahl, Camilla Noerfelt
AU - Henneberg, Marie
AU - Ried-Larsen, Mathias
AU - Nybing, Janus Damm
AU - Christensen, Robin
AU - Rosenmeier, Jaya Birgitte
AU - Karstoft, Kristian
AU - Pedersen, Bente Klarlund
AU - Ellingsgaard, Helga
AU - Krogh-Madsen, Rikke
N1 - Copyright © 2018 Elsevier Inc. All rights reserved.
PY - 2019/4/2
Y1 - 2019/4/2
N2 - Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade.
AB - Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade.
U2 - 10.1016/j.cmet.2018.12.007
DO - 10.1016/j.cmet.2018.12.007
M3 - Journal article
C2 - 30595477
VL - 29
SP - 844-855.e3
JO - Cell Metabolism
JF - Cell Metabolism
SN - 1550-4131
IS - 4
ER -