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Exercise and cancer: from "healthy" to "therapeutic"?

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Evidence of immune elimination, immuno-editing and immune escape in patients with hematological cancer

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Arginase-1-based vaccination against the tumor microenvironment: the identification of an optimal T-cell epitope

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. TAM-ing T cells in the tumor microenvironment: implications for TAM receptor targeting

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Tumor-induced escape mechanisms and their association with resistance to checkpoint inhibitor therapy

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  5. Cancer immunotherapy in patients with brain metastases

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. TAM-ing T cells in the tumor microenvironment: implications for TAM receptor targeting

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Inflammation induced PD-L1-specific T cells

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. MERTK Acts as a Costimulatory Receptor on Human CD8+ T Cells

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Expression and function of Kv1.3 channel in malignant T cells in Sézary syndrome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Exercise improves functional capacity and patient-reported outcomes across a range of cancer diagnoses. The mechanisms behind this protection have been largely unknown, but exercise-mediated changes in body composition, sex hormone levels, systemic inflammation, and immune cell function have been suggested to play a role. We recently demonstrated that voluntary exercise leads to an influx of immune cells in tumors, and a more than 60% reduction in tumor incidence and growth across several mouse models. Given the common mechanisms of immune cell mobilization in mouse and man during exercise, we hypothesize that this link between exercise and the immune system can be exploited in cancer therapy in particular in combination with immunotherapy. Thus, we believe that exercise may not just be "healthy" but may in fact be therapeutic.

OriginalsprogEngelsk
TidsskriftCancer immunology, immunotherapy : CII
Vol/bind66
Udgave nummer5
Sider (fra-til)667-671
Antal sider5
ISSN0340-7004
DOI
StatusUdgivet - maj 2017

ID: 52221612