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Exercise and cancer: from "healthy" to "therapeutic"?

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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  2. Expression and function of Kv1.3 channel in malignant T cells in Sézary syndrome

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  3. Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma

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  4. Withdrawal: Identification of tumor antigens among the HLA peptidomes of glioblastoma tumors and plasma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Collagen density regulates the activity of tumor-infiltrating T cells

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Vis graf over relationer

Exercise improves functional capacity and patient-reported outcomes across a range of cancer diagnoses. The mechanisms behind this protection have been largely unknown, but exercise-mediated changes in body composition, sex hormone levels, systemic inflammation, and immune cell function have been suggested to play a role. We recently demonstrated that voluntary exercise leads to an influx of immune cells in tumors, and a more than 60% reduction in tumor incidence and growth across several mouse models. Given the common mechanisms of immune cell mobilization in mouse and man during exercise, we hypothesize that this link between exercise and the immune system can be exploited in cancer therapy in particular in combination with immunotherapy. Thus, we believe that exercise may not just be "healthy" but may in fact be therapeutic.

OriginalsprogEngelsk
TidsskriftCancer immunology, immunotherapy : CII
Vol/bind66
Udgave nummer5
Sider (fra-til)667-671
Antal sider5
ISSN0340-7004
DOI
StatusUdgivet - maj 2017

ID: 52221612