TY - JOUR
T1 - Executive Summary of the Second International Guidelines for the Diagnosis and Management of Pediatric Acute Respiratory Distress Syndrome (PALICC-2)
AU - Emeriaud, Guillaume
AU - López-Fernández, Yolanda M
AU - Iyer, Narayan Prabhu
AU - Bembea, Melania M
AU - Agulnik, Asya
AU - Barbaro, Ryan P
AU - Baudin, Florent
AU - Bhalla, Anoopindar
AU - Brunow de Carvalho, Werther
AU - Carroll, Christopher L
AU - Cheifetz, Ira M
AU - Chisti, Mohammod J
AU - Cruces, Pablo
AU - Curley, Martha A Q
AU - Dahmer, Mary K
AU - Dalton, Heidi J
AU - Erickson, Simon J
AU - Essouri, Sandrine
AU - Fernández, Analía
AU - Flori, Heidi R
AU - Grunwell, Jocelyn R
AU - Jouvet, Philippe
AU - Killien, Elizabeth Y
AU - Kneyber, Martin C J
AU - Kudchadkar, Sapna R
AU - Korang, Steven Kwasi
AU - Lee, Jan Hau
AU - Macrae, Duncan J
AU - Maddux, Aline
AU - Modesto I Alapont, Vicent
AU - Morrow, Brenda M
AU - Nadkarni, Vinay M
AU - Napolitano, Natalie
AU - Newth, Christopher J L
AU - Pons-Odena, Martí
AU - Quasney, Michael W
AU - Rajapreyar, Prakadeshwari
AU - Rambaud, Jerome
AU - Randolph, Adrienne G
AU - Rimensberger, Peter
AU - Rowan, Courtney M
AU - Sanchez-Pinto, L Nelson
AU - Sapru, Anil
AU - Sauthier, Michael
AU - Shein, Steve L
AU - Smith, Lincoln S
AU - Steffen, Katerine
AU - Takeuchi, Muneyuki
AU - Thomas, Neal J
AU - Tse, Sze Man
AU - Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) Group on behalf of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
N1 - Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - OBJECTIVES: We sought to update our 2015 work in the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) guidelines for the diagnosis and management of pediatric acute respiratory distress syndrome (PARDS), considering new evidence and topic areas that were not previously addressed.DESIGN: International consensus conference series involving 52 multidisciplinary international content experts in PARDS and four methodology experts from 15 countries, using consensus conference methodology, and implementation science.SETTING: Not applicable.PATIENTS: Patients with or at risk for PARDS.INTERVENTIONS: None.MEASUREMENTS AND MAIN RESULTS: Eleven subgroups conducted systematic or scoping reviews addressing 11 topic areas: 1) definition, incidence, and epidemiology; 2) pathobiology, severity, and risk stratification; 3) ventilatory support; 4) pulmonary-specific ancillary treatment; 5) nonpulmonary treatment; 6) monitoring; 7) noninvasive respiratory support; 8) extracorporeal support; 9) morbidity and long-term outcomes; 10) clinical informatics and data science; and 11) resource-limited settings. The search included MEDLINE, EMBASE, and CINAHL Complete (EBSCOhost) and was updated in March 2022. Grading of Recommendations, Assessment, Development, and Evaluation methodology was used to summarize evidence and develop the recommendations, which were discussed and voted on by all PALICC-2 experts. There were 146 recommendations and statements, including: 34 recommendations for clinical practice; 112 consensus-based statements with 18 on PARDS definition, 55 on good practice, seven on policy, and 32 on research. All recommendations and statements had agreement greater than 80%.CONCLUSIONS: PALICC-2 recommendations and consensus-based statements should facilitate the implementation and adherence to the best clinical practice in patients with PARDS. These results will also inform the development of future programs of research that are crucially needed to provide stronger evidence to guide the pediatric critical care teams managing these patients.
AB - OBJECTIVES: We sought to update our 2015 work in the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) guidelines for the diagnosis and management of pediatric acute respiratory distress syndrome (PARDS), considering new evidence and topic areas that were not previously addressed.DESIGN: International consensus conference series involving 52 multidisciplinary international content experts in PARDS and four methodology experts from 15 countries, using consensus conference methodology, and implementation science.SETTING: Not applicable.PATIENTS: Patients with or at risk for PARDS.INTERVENTIONS: None.MEASUREMENTS AND MAIN RESULTS: Eleven subgroups conducted systematic or scoping reviews addressing 11 topic areas: 1) definition, incidence, and epidemiology; 2) pathobiology, severity, and risk stratification; 3) ventilatory support; 4) pulmonary-specific ancillary treatment; 5) nonpulmonary treatment; 6) monitoring; 7) noninvasive respiratory support; 8) extracorporeal support; 9) morbidity and long-term outcomes; 10) clinical informatics and data science; and 11) resource-limited settings. The search included MEDLINE, EMBASE, and CINAHL Complete (EBSCOhost) and was updated in March 2022. Grading of Recommendations, Assessment, Development, and Evaluation methodology was used to summarize evidence and develop the recommendations, which were discussed and voted on by all PALICC-2 experts. There were 146 recommendations and statements, including: 34 recommendations for clinical practice; 112 consensus-based statements with 18 on PARDS definition, 55 on good practice, seven on policy, and 32 on research. All recommendations and statements had agreement greater than 80%.CONCLUSIONS: PALICC-2 recommendations and consensus-based statements should facilitate the implementation and adherence to the best clinical practice in patients with PARDS. These results will also inform the development of future programs of research that are crucially needed to provide stronger evidence to guide the pediatric critical care teams managing these patients.
UR - http://www.scopus.com/inward/record.url?scp=85146827115&partnerID=8YFLogxK
U2 - 10.1097/PCC.0000000000003147
DO - 10.1097/PCC.0000000000003147
M3 - Journal article
C2 - 36661420
SN - 1529-7535
VL - 24
SP - 143
EP - 168
JO - Pediatric Critical Care Medicine
JF - Pediatric Critical Care Medicine
IS - 2
ER -