Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass

Carsten Dirksen; Kirstine N Bojsen-Møller; Nils B Jørgensen; Siv H Jacobsen; Viggo B Kristiansen; Lars S Naver; Dorte L Hansen; Dorte Worm; Jens Juul Holst; Sten Madsbad

doi:10.1007/s00125-013-3055-1

Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass

Carsten Dirksen, Kirstine N Bojsen-Møller, Nils B Jørgensen, Siv H Jacobsen, Viggo B Kristiansen, Lars S Naver, Dorte L Hansen, Dorte Worm, Jens Juul Holst, Sten Madsbad

80 Citationer (Scopus)

Abstract

Roux-en-Y gastric bypass (RYGB) improves glycaemic control in part by increasing postprandial insulin secretion through exaggerated glucagon-like peptide (GLP)-1 release. However, it is unknown whether islet cell responsiveness to i.v. glucose, non-glucose (arginine) and incretin hormones, including GLP-1, is altered.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	56
Udgave nummer	12
Sider (fra-til)	2679-87
Antal sider	9
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-013-3055-1
Status	Udgivet - dec. 2013

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10.1007/s00125-013-3055-1

Citationsformater

Dirksen, C., Bojsen-Møller, K. N., Jørgensen, N. B., Jacobsen, S. H., Kristiansen, V. B., Naver, L. S., Hansen, D. L., Worm, D., Holst, J. J., & Madsbad, S. (2013). Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass. Diabetologia, 56(12), 2679-87. https://doi.org/10.1007/s00125-013-3055-1

Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass. / Dirksen, Carsten ; Bojsen-Møller, Kirstine N; Jørgensen, Nils B et al.
I: Diabetologia, Bind 56, Nr. 12, 12.2013, s. 2679-87.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Dirksen, C , Bojsen-Møller, KN, Jørgensen, NB, Jacobsen, SH , Kristiansen, VB, Naver, LS, Hansen, DL , Worm, D, Holst, JJ & Madsbad, S 2013, 'Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass', Diabetologia, bind 56, nr. 12, s. 2679-87. https://doi.org/10.1007/s00125-013-3055-1

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abstract = "Roux-en-Y gastric bypass (RYGB) improves glycaemic control in part by increasing postprandial insulin secretion through exaggerated glucagon-like peptide (GLP)-1 release. However, it is unknown whether islet cell responsiveness to i.v. glucose, non-glucose (arginine) and incretin hormones, including GLP-1, is altered.",

author = "Carsten Dirksen and Bojsen-M{\o}ller, {Kirstine N} and J{\o}rgensen, {Nils B} and Jacobsen, {Siv H} and Kristiansen, {Viggo B} and Naver, {Lars S} and Hansen, {Dorte L} and Dorte Worm and Holst, {Jens Juul} and Sten Madsbad",

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doi = "10.1007/s00125-013-3055-1",

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AU - Dirksen, Carsten

AU - Bojsen-Møller, Kirstine N

AU - Jørgensen, Nils B

AU - Jacobsen, Siv H

AU - Kristiansen, Viggo B

AU - Naver, Lars S

AU - Hansen, Dorte L

AU - Worm, Dorte

AU - Holst, Jens Juul

AU - Madsbad, Sten

PY - 2013/12

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N2 - Roux-en-Y gastric bypass (RYGB) improves glycaemic control in part by increasing postprandial insulin secretion through exaggerated glucagon-like peptide (GLP)-1 release. However, it is unknown whether islet cell responsiveness to i.v. glucose, non-glucose (arginine) and incretin hormones, including GLP-1, is altered.

AB - Roux-en-Y gastric bypass (RYGB) improves glycaemic control in part by increasing postprandial insulin secretion through exaggerated glucagon-like peptide (GLP)-1 release. However, it is unknown whether islet cell responsiveness to i.v. glucose, non-glucose (arginine) and incretin hormones, including GLP-1, is altered.

U2 - 10.1007/s00125-013-3055-1

DO - 10.1007/s00125-013-3055-1

M3 - Journal article

C2 - 24048673

SN - 0012-186X

VL - 56

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EP - 2687

JO - Diabetologia

JF - Diabetologia

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ER -

Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass

Abstract

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