Ex vivo activity quantification in micrometastases at the cellular scale using the α-camera technique

Nicolas Chouin; Sture Lindegren; Sofia H L Frost; Holger Jensen; Per Albertsson; Ragnar Hultborn; Stig Palm; Lars Jacobsson; Tom Bäck

doi:10.2967/jnumed.112.113001

Ex vivo activity quantification in micrometastases at the cellular scale using the α-camera technique

Nicolas Chouin, Sture Lindegren, Sofia H L Frost, Holger Jensen, Per Albertsson, Ragnar Hultborn, Stig Palm, Lars Jacobsson, Tom Bäck

Afdeling for Klinisk Fysiologi og Nuklearmedicin DIA

28 Citationer (Scopus)

Abstract

Targeted α-therapy (TAT) appears to be an ideal therapeutic technique for eliminating malignant circulating, minimal residual, or micrometastatic cells. These types of malignancies are typically infraclinical, complicating the evaluation of potential treatments. This study presents a method of ex vivo activity quantification with an α-camera device, allowing measurement of the activity taken up by tumor cells in biologic structures a few tens of microns.

Originalsprog	Engelsk
Tidsskrift	Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Vol/bind	54
Udgave nummer	8
Sider (fra-til)	1347-53
Antal sider	7
ISSN	0161-5505
DOI	https://doi.org/10.2967/jnumed.112.113001
Status	Udgivet - aug. 2013

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10.2967/jnumed.112.113001

Citationsformater

Chouin, N., Lindegren, S., Frost, S. H. L., Jensen, H., Albertsson, P., Hultborn, R., Palm, S., Jacobsson, L., & Bäck, T. (2013). Ex vivo activity quantification in micrometastases at the cellular scale using the α-camera technique. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(8), 1347-53. https://doi.org/10.2967/jnumed.112.113001

Ex vivo activity quantification in micrometastases at the cellular scale using the α-camera technique. / Chouin, Nicolas; Lindegren, Sture; Frost, Sofia H L et al.
I: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Bind 54, Nr. 8, 08.2013, s. 1347-53.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Chouin, N, Lindegren, S, Frost, SHL, Jensen, H, Albertsson, P, Hultborn, R, Palm, S, Jacobsson, L & Bäck, T 2013, 'Ex vivo activity quantification in micrometastases at the cellular scale using the α-camera technique', Journal of nuclear medicine : official publication, Society of Nuclear Medicine, bind 54, nr. 8, s. 1347-53. https://doi.org/10.2967/jnumed.112.113001

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abstract = "Targeted α-therapy (TAT) appears to be an ideal therapeutic technique for eliminating malignant circulating, minimal residual, or micrometastatic cells. These types of malignancies are typically infraclinical, complicating the evaluation of potential treatments. This study presents a method of ex vivo activity quantification with an α-camera device, allowing measurement of the activity taken up by tumor cells in biologic structures a few tens of microns.",

keywords = "Alpha Particles, Animals, Calibration, Cell Line, Tumor, Female, Humans, Mice, Neoplasm Metastasis, Ovarian Neoplasms, Radiation Dosage, Radionuclide Imaging",

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doi = "10.2967/jnumed.112.113001",

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AU - Chouin, Nicolas

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AU - Frost, Sofia H L

AU - Jensen, Holger

AU - Albertsson, Per

AU - Hultborn, Ragnar

AU - Palm, Stig

AU - Jacobsson, Lars

AU - Bäck, Tom

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AB - Targeted α-therapy (TAT) appears to be an ideal therapeutic technique for eliminating malignant circulating, minimal residual, or micrometastatic cells. These types of malignancies are typically infraclinical, complicating the evaluation of potential treatments. This study presents a method of ex vivo activity quantification with an α-camera device, allowing measurement of the activity taken up by tumor cells in biologic structures a few tens of microns.

KW - Alpha Particles

KW - Animals

KW - Calibration

KW - Cell Line, Tumor

KW - Female

KW - Humans

KW - Mice

KW - Neoplasm Metastasis

KW - Ovarian Neoplasms

KW - Radiation Dosage

KW - Radionuclide Imaging

U2 - 10.2967/jnumed.112.113001

DO - 10.2967/jnumed.112.113001

M3 - Journal article

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JO - Journal of nuclear medicine : official publication, Society of Nuclear Medicine

JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine

IS - 8

ER -

Ex vivo activity quantification in micrometastases at the cellular scale using the α-camera technique

Abstract

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