Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Evidence-based practice within nutrition: what are the barriers for improving the evidence and how can they be dealt with?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Acupuncture for chronic hepatitis B (Protokol)

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Interventions for altering blood pressure in people with acute subarachnoid haemorrhage (Protocol)

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Radix Sophorae flavescentis for chronic hepatitis B (Protocol)

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Radix Sophorae flavescentis versus antiviral drugs for chronic hepatitis B (Protocol)

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  • Martine Laville
  • Berenice Segrestin
  • Maud Alligier
  • Cristina Ruano-Rodríguez
  • Lluis Serra-Majem
  • Michael Hiesmayr
  • Annemie M W J Schols
  • Carlo La Vecchia
  • Yves Boirie
  • Ana Rath
  • Edmund A M Neugebauer
  • Silvio Garattini
  • Vittorio Bertele'
  • Christine Kubiak
  • Jacques Demotes-Mainard
  • Janus C Jakobsen
  • Snezana Djurisic
  • Christian Gluud
Vis graf over relationer

BACKGROUND: Evidence-based clinical research poses special barriers in the field of nutrition. The present review summarises the main barriers to research in the field of nutrition that are not common to all randomised clinical trials or trials on rare diseases and highlights opportunities for improvements.

METHODS: Systematic academic literature searches and internal European Clinical Research Infrastructure Network (ECRIN) communications during face-to-face meetings and telephone conferences from 2013 to 2017 within the context of the ECRIN Integrating Activity (ECRIN-IA) project.

RESULTS: Many nutrients occur in multiple forms that differ in biological activity, and several factors can alter their bioavailability which raises barriers to their assessment. These include specific difficulties with blinding procedures, with assessments of dietary intake, and with selecting appropriate outcomes as patient-centred outcomes may occur decennia into the future. The methodologies and regulations for drug trials are, however, applicable to nutrition trials.

CONCLUSIONS: Research on clinical nutrition should start by collecting clinical data systematically in databases and registries. Measurable patient-centred outcomes and appropriate study designs are needed. International cooperation and multistakeholder engagement are key for success.

OriginalsprogEngelsk
TidsskriftTrials
Vol/bind18
Tidsskriftsnummer1
Sider (fra-til)425
ISSN1745-6215
DOI
StatusUdgivet - 11 sep. 2017

ID: 51687715