Evidence-Based Therapy and Its Association With Workforce Detachment After First Hospitalization for Heart Failure

Rasmus Rørth, Emil L Fosbøl, Ulrik M Mogensen, Kristian Kragholm, Pardeep S Jhund, Mark C Petrie, Morten Schou, Gunnar H Gislason, John J V McMurray, Christian Torp-Pedersen, Lars Køber, Søren L Kristensen

5 Citationer (Scopus)


OBJECTIVES: This study investigated the association between the use of evidence-based medicine (EBM) for heart failure (HF) and risk of workforce detachment.

BACKGROUND: The ability to work can be a marker of functional capacity and quality of life.

METHODS: We examined a nationwide cohort of patients in the workforce 1 year after first hospitalization for HF. EBM was defined as treatment with β-blockers and renin angiotensin system inhibitors. The fraction of target dose (0 TO 1) for each drug was calculated. The sum of the fractions gave each patient a score between 0 and 2. Patients were stratified into 4 groups according to this score: group 4 score = 2 (target dose of both drugs); group 3 score <2 to >1; group 2 score ≤1 to >0.5; and group 1 score ≤0.5. The risk of subsequent workforce detachment was estimated in cause specific Cox regression models.

RESULTS: One year after first HF hospitalization, 10,185 patients were part of the workforce, and 7,561 (74%) were in treatment with at least 1 of the components of EBM. During a median follow-up of 727 days, 2,698 individuals (36%) became detached from the workforce. Patients receiving more EBM had a significantly lower risk of workforce detachment compared with those receiving less EBM (group 4 hazard ratio [HR]: 0.87; 95% confidence interval [CI]: 0.77 to 0.98; group 3 HR: 0.85; 95% CI: 0.77 to 0.94; and group 2 HR 0.92; 95% CI: 0.83 to 1.02), all compared to group 1.

CONCLUSIONS: Patients in the workforce 1 year after first HF hospitalization and treated with target or near-target doses of EBM were associated with a significantly lower risk of subsequent workforce detachment.

TidsskriftJACC. Heart failure
Udgave nummer1
Sider (fra-til)41-48
Antal sider8
StatusUdgivet - jan. 2018


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