Evidence-based guidelines for the pharmacological treatment of migraine, summary version

Raffaele Ornello; Valeria Caponnetto; Fayyaz Ahmed; Haidar M Al-Khazali; Anna Ambrosini; Sait Ashina; Carlo Baraldi; Alessia Bellotti; Filippo Brighina; Paolo Calabresi; Francesco Casillo; Sabina Cevoli; Shuli Cheng; Chia-Chun Chiang; Alberto Chiarugi; Rune Häckert Christensen; Min Kyung Chu; Gianluca Coppola; Ilenia Corbelli; Santiago Crema; Roberto De Icco; Marina De Tommaso; Cherubino Di Lorenzo; Vincenzo Di Stefano; Hans-Christoph Diener; Esme Ekizoglu; Adriana Fallacara; Valentina Favoni; Kimberly N Garces; Pierangelo Geppetti; Maria Teresa Goicochea; Antonio Granato; Franco Granella; Simona Guerzoni; Woo-Seok Ha; Amr Hassan; Koichi Hirata; Jan Hoffmann; Eva-Maria Hüssler; Mona Hussein; Luigi Francesco Iannone; Bronwyn Jenkins; Alejandro Labastida-Ramirez; Anna Laporta; Morris Levin; Antonino Lupica; Edoardo Mampreso; Daniele Martinelli; Teshamae S Monteith; Ilaria Orologio; Aynur Özge; Li-Ling Hope Pan; Lavindren Luke Panneerchelvam; Mario Fp Peres; Marcio Nattan Portes Souza; Patricia Pozo-Rosich; Maria Pia Prudenzano; Silvia Quattrocchi; Innocenzo Rainero; Volodymyr Romanenko; Marina Romozzi; Antonio Russo; Grazia Sances; Paola Sarchielli; Todd J Schwedt; Marcello Silvestro; Diego Belardino Swerts; Cristina Tassorelli; Alessandro Tessitore; Mansoureh Togha; Gloria Vaghi; Shuu-Jiun Wang; Messoud Ashina; Simona Sacco

doi:10.1177/03331024251321500

Evidence-based guidelines for the pharmacological treatment of migraine, summary version

Raffaele Ornello, Valeria Caponnetto, Fayyaz Ahmed, Haidar M Al-Khazali, Anna Ambrosini, Sait Ashina, Carlo Baraldi, Alessia Bellotti, Filippo Brighina, Paolo Calabresi, Francesco Casillo, Sabina Cevoli, Shuli Cheng, Chia-Chun Chiang, Alberto Chiarugi, Rune Häckert Christensen, Min Kyung Chu, Gianluca Coppola, Ilenia Corbelli, Santiago CremaRoberto De Icco, Marina De Tommaso, Cherubino Di Lorenzo, Vincenzo Di Stefano, Hans-Christoph Diener, Esme Ekizoglu, Adriana Fallacara, Valentina Favoni, Kimberly N Garces, Pierangelo Geppetti, Maria Teresa Goicochea, Antonio Granato, Franco Granella, Simona Guerzoni, Woo-Seok Ha, Amr Hassan, Koichi Hirata, Jan Hoffmann, Eva-Maria Hüssler, Mona Hussein, Luigi Francesco Iannone, Bronwyn Jenkins, Alejandro Labastida-Ramirez, Anna Laporta, Morris Levin, Antonino Lupica, Edoardo Mampreso, Daniele Martinelli, Teshamae S Monteith, Ilaria Orologio, Aynur Özge, Li-Ling Hope Pan, Lavindren Luke Panneerchelvam, Mario Fp Peres, Marcio Nattan Portes Souza, Patricia Pozo-Rosich, Maria Pia Prudenzano, Silvia Quattrocchi, Innocenzo Rainero, Volodymyr Romanenko, Marina Romozzi, Antonio Russo, Grazia Sances, Paola Sarchielli, Todd J Schwedt, Marcello Silvestro, Diego Belardino Swerts, Cristina Tassorelli, Alessandro Tessitore, Mansoureh Togha, Gloria Vaghi, Shuu-Jiun Wang, Messoud Ashina, Simona Sacco^*

^*Corresponding author af dette arbejde

Afdeling for Hjerne- og Nervesygdomme NEU

22 Citationer (Scopus)

Abstract

We here present evidence-based guidelines for the pharmacological treatment of migraine. These guidelines, created by the Italian Society for the Study of Headache and the International Headache Society, aim to offer clear, actionable recommendations to healthcare professionals. They incorporate evidence-based recommendations from randomized controlled trials and expert-based opinions. The guidelines follow the GRADE approach for assessing the quality of evidence. The guideline development involved a systematic review of literature across multiple databases, adherence to Cochrane review methods, and a structured framework for data extraction and interpretation. Although the guidelines provide a robust foundation for migraine treatment, they also highlight gaps in current research, such as the paucity of head-to-head drug comparisons and the need for long-term outcome studies. These guidelines serve as a resource to standardize migraine treatment and promote high-quality care across different healthcare settings.

Originalsprog	Engelsk
Tidsskrift	Cephalalgia : an international journal of headache
Vol/bind	45
Udgave nummer	4
Sider (fra-til)	3331024251321500
ISSN	0333-1024
DOI	https://doi.org/10.1177/03331024251321500
Status	Udgivet - apr. 2025

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10.1177/03331024251321500Licens: CC BY-NC

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Ornello, R., Caponnetto, V., Ahmed, F., Al-Khazali, H. M., Ambrosini, A., Ashina, S., Baraldi, C., Bellotti, A., Brighina, F., Calabresi, P., Casillo, F., Cevoli, S., Cheng, S., Chiang, C.-C., Chiarugi, A., Christensen, R. H., Chu, M. K., Coppola, G., Corbelli, I., ... Sacco, S. (2025). Evidence-based guidelines for the pharmacological treatment of migraine, summary version. Cephalalgia : an international journal of headache, 45(4), 3331024251321500. https://doi.org/10.1177/03331024251321500

Ornello, R, Caponnetto, V, Ahmed, F, Al-Khazali, HM, Ambrosini, A, Ashina, S, Baraldi, C, Bellotti, A, Brighina, F, Calabresi, P, Casillo, F, Cevoli, S, Cheng, S, Chiang, C-C, Chiarugi, A, Christensen, RH, Chu, MK, Coppola, G, Corbelli, I, Crema, S, De Icco, R, De Tommaso, M, Di Lorenzo, C, Di Stefano, V, Diener, H-C, Ekizoglu, E, Fallacara, A, Favoni, V, Garces, KN, Geppetti, P, Goicochea, MT, Granato, A, Granella, F, Guerzoni, S, Ha, W-S, Hassan, A, Hirata, K, Hoffmann, J, Hüssler, E-M, Hussein, M, Iannone, LF, Jenkins, B, Labastida-Ramirez, A, Laporta, A, Levin, M, Lupica, A, Mampreso, E, Martinelli, D, Monteith, TS, Orologio, I, Özge, A, Pan, L-LH, Panneerchelvam, LL, Peres, MF, Souza, MNP, Pozo-Rosich, P, Prudenzano, MP, Quattrocchi, S, Rainero, I, Romanenko, V, Romozzi, M, Russo, A, Sances, G, Sarchielli, P, Schwedt, TJ, Silvestro, M, Swerts, DB, Tassorelli, C, Tessitore, A, Togha, M, Vaghi, G, Wang, S-J, Ashina, M & Sacco, S 2025, 'Evidence-based guidelines for the pharmacological treatment of migraine, summary version', Cephalalgia : an international journal of headache, bind 45, nr. 4, s. 3331024251321500. https://doi.org/10.1177/03331024251321500

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abstract = "We here present evidence-based guidelines for the pharmacological treatment of migraine. These guidelines, created by the Italian Society for the Study of Headache and the International Headache Society, aim to offer clear, actionable recommendations to healthcare professionals. They incorporate evidence-based recommendations from randomized controlled trials and expert-based opinions. The guidelines follow the GRADE approach for assessing the quality of evidence. The guideline development involved a systematic review of literature across multiple databases, adherence to Cochrane review methods, and a structured framework for data extraction and interpretation. Although the guidelines provide a robust foundation for migraine treatment, they also highlight gaps in current research, such as the paucity of head-to-head drug comparisons and the need for long-term outcome studies. These guidelines serve as a resource to standardize migraine treatment and promote high-quality care across different healthcare settings.",

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AU - Ornello, Raffaele

AU - Caponnetto, Valeria

AU - Ahmed, Fayyaz

AU - Al-Khazali, Haidar M

AU - Ambrosini, Anna

AU - Ashina, Sait

AU - Baraldi, Carlo

AU - Bellotti, Alessia

AU - Brighina, Filippo

AU - Calabresi, Paolo

AU - Casillo, Francesco

AU - Cevoli, Sabina

AU - Cheng, Shuli

AU - Chiang, Chia-Chun

AU - Chiarugi, Alberto

AU - Christensen, Rune Häckert

AU - Chu, Min Kyung

AU - Coppola, Gianluca

AU - Corbelli, Ilenia

AU - Crema, Santiago

AU - De Icco, Roberto

AU - De Tommaso, Marina

AU - Di Lorenzo, Cherubino

AU - Di Stefano, Vincenzo

AU - Diener, Hans-Christoph

AU - Ekizoglu, Esme

AU - Fallacara, Adriana

AU - Favoni, Valentina

AU - Garces, Kimberly N

AU - Geppetti, Pierangelo

AU - Goicochea, Maria Teresa

AU - Granato, Antonio

AU - Granella, Franco

AU - Guerzoni, Simona

AU - Ha, Woo-Seok

AU - Hassan, Amr

AU - Hirata, Koichi

AU - Hoffmann, Jan

AU - Hüssler, Eva-Maria

AU - Hussein, Mona

AU - Iannone, Luigi Francesco

AU - Jenkins, Bronwyn

AU - Labastida-Ramirez, Alejandro

AU - Laporta, Anna

AU - Levin, Morris

AU - Lupica, Antonino

AU - Mampreso, Edoardo

AU - Martinelli, Daniele

AU - Monteith, Teshamae S

AU - Orologio, Ilaria

AU - Özge, Aynur

AU - Pan, Li-Ling Hope

AU - Panneerchelvam, Lavindren Luke

AU - Peres, Mario Fp

AU - Souza, Marcio Nattan Portes

AU - Pozo-Rosich, Patricia

AU - Prudenzano, Maria Pia

AU - Quattrocchi, Silvia

AU - Rainero, Innocenzo

AU - Romanenko, Volodymyr

AU - Romozzi, Marina

AU - Russo, Antonio

AU - Sances, Grazia

AU - Sarchielli, Paola

AU - Schwedt, Todd J

AU - Silvestro, Marcello

AU - Swerts, Diego Belardino

AU - Tassorelli, Cristina

AU - Tessitore, Alessandro

AU - Togha, Mansoureh

AU - Vaghi, Gloria

AU - Wang, Shuu-Jiun

AU - Ashina, Messoud

AU - Sacco, Simona

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AB - We here present evidence-based guidelines for the pharmacological treatment of migraine. These guidelines, created by the Italian Society for the Study of Headache and the International Headache Society, aim to offer clear, actionable recommendations to healthcare professionals. They incorporate evidence-based recommendations from randomized controlled trials and expert-based opinions. The guidelines follow the GRADE approach for assessing the quality of evidence. The guideline development involved a systematic review of literature across multiple databases, adherence to Cochrane review methods, and a structured framework for data extraction and interpretation. Although the guidelines provide a robust foundation for migraine treatment, they also highlight gaps in current research, such as the paucity of head-to-head drug comparisons and the need for long-term outcome studies. These guidelines serve as a resource to standardize migraine treatment and promote high-quality care across different healthcare settings.

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KW - Humans

KW - Evidence-Based Medicine/standards

KW - Analgesics/therapeutic use

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JO - Cephalalgia : an international journal of headache

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Evidence-based guidelines for the pharmacological treatment of migraine, summary version

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