Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Evaluation of the microdialysis technique in the dog fat pad

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Mechanisms of inhibition of vasopressin release during moderate antiorthostatic posture change in humans

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cardiovascular, endocrine, and renal effects of urodilatin in normal humans

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Fat metabolism in formerly obese women

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Effect of training on epinephrine-stimulated lipolysis determined by microdialysis in human adipose tissue

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Increased oral sodium chloride intake in humans amplifies selectively postprandial GLP-1 but not GIP, CCK, and gastrin in plasma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Extracellular fluid volume expansion uncovers a natriuretic action of GLP-1: a functional GLP-1-renal axis in man

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. GIP-induced vasodilation in human adipose tissue involves capillary recruitment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
In the present study the microdialysis technique was evaluated in an isolated autoperfused dog fat pad. Concentrations of glucose, lactate, and glycerol were measured in interstitial fluid by microdialysis and simultaneously in arterial and adipose venous plasma. Adipose tissue blood flow was measured by both 133Xe washout and timed weighing of venous blood. Metabolite concentrations in adipose venous plasma calculated from interstitial and arterial metabolite concentrations and 133Xe washout were positively correlated with measured venous concentrations (glucose: r = 0.95, lactate: r = 0.92, glycerol: r = 0.81). Calculated and measured venous plasma concentrations did not differ for either glucose or lactate, but for glycerol, calculated concentration was on average 76% of measured concentration. Metabolite exchanges (Fick's principle) calculated from interstitial metabolite concentrations were positively correlated with measured exchanges only for lactate (r = 0.69). In conclusion, metabolite concentrations in adipose venous plasma can be calculated from microdialysis measurements with greater accuracy for glucose and lactate than for glycerol. The precision, however, is too low to allow calculation of metabolite exchange when arteriovenous metabolite differences are low.
OriginalsprogEngelsk
TidsskriftAmerican Journal of Physiology (Consolidated)
Vol/bind276
Udgave nummer3 Pt 1
Sider (fra-til)E588-95
ISSN0002-9513
StatusUdgivet - mar. 1999

ID: 39022277