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Region Hovedstaden - en del af Københavns Universitetshospital
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Evaluation of Caspofungin Susceptibility Testing by the New Vitek 2 AST-YS06 Yeast Card Using a Unique Collection of FKS Wild-Type and Hot Spot Mutant Isolates, Including the Five Most Common Candida Species

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  3. Bacterial persisters in long-term infection: Emergence and fitness in a complex host environment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Gene Loss and Acquisition in Lineages of Pseudomonas aeruginosa Evolving in Cystic Fibrosis Patient Airways

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Vis graf over relationer
FKS mutant isolates associated with breakthrough or failure cases are emerging in clinical settings. Discrimination of these from wild-type (wt) isolates in a routine laboratory setting is complicated. We evaluated the ability of caspofungin MIC determination using the new Vitek 2 AST-Y06 yeast susceptibility card to correctly identify the fks mutants from wt isolates and compared the performance to those of the CLSI and EUCAST reference methods. A collection of 98 Candida isolates, including 31 fks hot spot mutants, were included. Performance was evaluated using the FKS genotype as the "gold standard" and compared to those of the CLSI and EUCAST methodologies. The categorical agreement for Vitek 2 was 93.9%, compared to 88.4% for the CLSI method and 98.7% for the EUCAST method. Vitek 2 misclassified 19.4% (6/31) of the fks mutant isolates as susceptible, in contrast to
OriginalsprogEngelsk
TidsskriftAntimicrobial Agents and Chemotherapy
Vol/bind57
Udgave nummer1
Sider (fra-til)177-82
Antal sider6
ISSN0066-4804
DOI
StatusUdgivet - 2013

ID: 36768535