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Evaluation of an ICD-10 algorithm to detect osteonecrosis of the jaw among cancer patients in the Danish National Registry of Patients

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Harvard

Ehrenstein, V, Gammelager, H, Schiødt, M, Nørholt, SE, Neumann-Jensen, B, Folkmar, TB, Pedersen, L, Svaerke, C, Sørensen, HT, Ma, H & Acquavella, J 2015, 'Evaluation of an ICD-10 algorithm to detect osteonecrosis of the jaw among cancer patients in the Danish National Registry of Patients', Pharmacoepidemiology and Drug Safety, bind 24, nr. 7, s. 693-700. https://doi.org/10.1002/pds.3786

APA

Ehrenstein, V., Gammelager, H., Schiødt, M., Nørholt, S. E., Neumann-Jensen, B., Folkmar, T. B., Pedersen, L., Svaerke, C., Sørensen, H. T., Ma, H., & Acquavella, J. (2015). Evaluation of an ICD-10 algorithm to detect osteonecrosis of the jaw among cancer patients in the Danish National Registry of Patients. Pharmacoepidemiology and Drug Safety, 24(7), 693-700. https://doi.org/10.1002/pds.3786

CBE

Ehrenstein V, Gammelager H, Schiødt M, Nørholt SE, Neumann-Jensen B, Folkmar TB, Pedersen L, Svaerke C, Sørensen HT, Ma H, Acquavella J. 2015. Evaluation of an ICD-10 algorithm to detect osteonecrosis of the jaw among cancer patients in the Danish National Registry of Patients. Pharmacoepidemiology and Drug Safety. 24(7):693-700. https://doi.org/10.1002/pds.3786

MLA

Vancouver

Author

Ehrenstein, Vera ; Gammelager, Henrik ; Schiødt, Morten ; Nørholt, Sven Erik ; Neumann-Jensen, Bjarne ; Folkmar, Troels Bille ; Pedersen, Lars ; Svaerke, Claus ; Sørensen, Henrik Toft ; Ma, Haijun ; Acquavella, John. / Evaluation of an ICD-10 algorithm to detect osteonecrosis of the jaw among cancer patients in the Danish National Registry of Patients. I: Pharmacoepidemiology and Drug Safety. 2015 ; Bind 24, Nr. 7. s. 693-700.

Bibtex

@article{2e2c699686104330b55e6b09776d2200,
title = "Evaluation of an ICD-10 algorithm to detect osteonecrosis of the jaw among cancer patients in the Danish National Registry of Patients",
abstract = "PURPOSE: This study aimed to validate a predefined algorithm for osteonecrosis of the jaw (ONJ) among cancer patients in the Danish National Registry of Patients and to assess the nature of clinical information recorded in medical charts of ONJ patients.METHODS: We identified potential ONJ cases recorded in 2005-2010 among cancer patients at the hospital Departments of Oral and Maxillofacial Surgery (DOMS) in three Danish regions, using a set of codes from the International Classification of Diseases, 10th revision (ICD-10). We abstracted DOMS charts of the potential cases, had the ONJ status adjudicated by an expert ONJ adjudication committee (ONJAC), and computed positive predictive values. For patients with ONJAC-confirmed ONJ, we abstracted the charts for information on ONJ clinical course. Sensitivity of the algorithm was computed using a separate sample of 101 known ONJ cases accrued in 2005-2011.RESULTS: We identified 212 potential ONJ cases, of which 197 (93%) had charts available for abstraction. Eighty-three potential cases were confirmed by ONJAC, with a positive predictive value of 42% (95% confidence interval [CI] 35%-49%). DOMS charts of these 83 cases contained complete information on ONJ clinical course. Information about antiresorptive treatment was recorded for 84% of the patients. Among the 101 known ONJ cases, 74 had at least one prespecified ICD-10 code recorded in the Danish National Registry of Patients within ±90 days of the ONJ diagnosis (sensitivity 73%; 95%CI [64%-81%]).CONCLUSIONS: The predefined algorithm is not adequate for monitoring ONJ in pharmacovigilance studies. Additional case-finding approaches, coupled with adjudication, are necessary to estimate ONJ incidence accurately.",
author = "Vera Ehrenstein and Henrik Gammelager and Morten Schi{\o}dt and N{\o}rholt, {Sven Erik} and Bjarne Neumann-Jensen and Folkmar, {Troels Bille} and Lars Pedersen and Claus Svaerke and S{\o}rensen, {Henrik Toft} and Haijun Ma and John Acquavella",
note = "Copyright {\textcopyright} 2015 John Wiley & Sons, Ltd.",
year = "2015",
month = jul,
doi = "10.1002/pds.3786",
language = "English",
volume = "24",
pages = "693--700",
journal = "Pharmacoepidemiology and Drug Safety",
issn = "1053-8569",
publisher = "John/Wiley & Sons Ltd",
number = "7",

}

RIS

TY - JOUR

T1 - Evaluation of an ICD-10 algorithm to detect osteonecrosis of the jaw among cancer patients in the Danish National Registry of Patients

AU - Ehrenstein, Vera

AU - Gammelager, Henrik

AU - Schiødt, Morten

AU - Nørholt, Sven Erik

AU - Neumann-Jensen, Bjarne

AU - Folkmar, Troels Bille

AU - Pedersen, Lars

AU - Svaerke, Claus

AU - Sørensen, Henrik Toft

AU - Ma, Haijun

AU - Acquavella, John

N1 - Copyright © 2015 John Wiley & Sons, Ltd.

PY - 2015/7

Y1 - 2015/7

N2 - PURPOSE: This study aimed to validate a predefined algorithm for osteonecrosis of the jaw (ONJ) among cancer patients in the Danish National Registry of Patients and to assess the nature of clinical information recorded in medical charts of ONJ patients.METHODS: We identified potential ONJ cases recorded in 2005-2010 among cancer patients at the hospital Departments of Oral and Maxillofacial Surgery (DOMS) in three Danish regions, using a set of codes from the International Classification of Diseases, 10th revision (ICD-10). We abstracted DOMS charts of the potential cases, had the ONJ status adjudicated by an expert ONJ adjudication committee (ONJAC), and computed positive predictive values. For patients with ONJAC-confirmed ONJ, we abstracted the charts for information on ONJ clinical course. Sensitivity of the algorithm was computed using a separate sample of 101 known ONJ cases accrued in 2005-2011.RESULTS: We identified 212 potential ONJ cases, of which 197 (93%) had charts available for abstraction. Eighty-three potential cases were confirmed by ONJAC, with a positive predictive value of 42% (95% confidence interval [CI] 35%-49%). DOMS charts of these 83 cases contained complete information on ONJ clinical course. Information about antiresorptive treatment was recorded for 84% of the patients. Among the 101 known ONJ cases, 74 had at least one prespecified ICD-10 code recorded in the Danish National Registry of Patients within ±90 days of the ONJ diagnosis (sensitivity 73%; 95%CI [64%-81%]).CONCLUSIONS: The predefined algorithm is not adequate for monitoring ONJ in pharmacovigilance studies. Additional case-finding approaches, coupled with adjudication, are necessary to estimate ONJ incidence accurately.

AB - PURPOSE: This study aimed to validate a predefined algorithm for osteonecrosis of the jaw (ONJ) among cancer patients in the Danish National Registry of Patients and to assess the nature of clinical information recorded in medical charts of ONJ patients.METHODS: We identified potential ONJ cases recorded in 2005-2010 among cancer patients at the hospital Departments of Oral and Maxillofacial Surgery (DOMS) in three Danish regions, using a set of codes from the International Classification of Diseases, 10th revision (ICD-10). We abstracted DOMS charts of the potential cases, had the ONJ status adjudicated by an expert ONJ adjudication committee (ONJAC), and computed positive predictive values. For patients with ONJAC-confirmed ONJ, we abstracted the charts for information on ONJ clinical course. Sensitivity of the algorithm was computed using a separate sample of 101 known ONJ cases accrued in 2005-2011.RESULTS: We identified 212 potential ONJ cases, of which 197 (93%) had charts available for abstraction. Eighty-three potential cases were confirmed by ONJAC, with a positive predictive value of 42% (95% confidence interval [CI] 35%-49%). DOMS charts of these 83 cases contained complete information on ONJ clinical course. Information about antiresorptive treatment was recorded for 84% of the patients. Among the 101 known ONJ cases, 74 had at least one prespecified ICD-10 code recorded in the Danish National Registry of Patients within ±90 days of the ONJ diagnosis (sensitivity 73%; 95%CI [64%-81%]).CONCLUSIONS: The predefined algorithm is not adequate for monitoring ONJ in pharmacovigilance studies. Additional case-finding approaches, coupled with adjudication, are necessary to estimate ONJ incidence accurately.

U2 - 10.1002/pds.3786

DO - 10.1002/pds.3786

M3 - Journal article

C2 - 25974710

VL - 24

SP - 693

EP - 700

JO - Pharmacoepidemiology and Drug Safety

JF - Pharmacoepidemiology and Drug Safety

SN - 1053-8569

IS - 7

ER -

ID: 46231108