Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Evaluation of an ICD-10 algorithm to detect osteonecrosis of the jaw among cancer patients in the Danish National Registry of Patients

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Tramadol use in Norway: A register-based population study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Multi-centre, multi-database studies with common protocols: Lessons learnt from the IMI PROTECT project

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Hypnotics and mortality--partial confounding by disease, substance abuse and socioeconomic factors?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Use of quinine and mortality-risk in patients with heart failure-a Danish nationwide observational study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Workshop of European task force on medication-related osteonecrosis of the jaw-Current challenges

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Symptomer fra mundhulen

    Publikation: Bidrag til bog/antologi/rapportBidrag til kompendium/lecture notesUndervisningpeer review

  3. Drugs and diseases: Summary and consensus statements of group 1. The 5th EAO Consensus Conference 2018

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The effect of antiresorptive drugs on implant therapy: Systematic review and meta-analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Vera Ehrenstein
  • Henrik Gammelager
  • Morten Schiødt
  • Sven Erik Nørholt
  • Bjarne Neumann-Jensen
  • Troels Bille Folkmar
  • Lars Pedersen
  • Claus Svaerke
  • Henrik Toft Sørensen
  • Haijun Ma
  • John Acquavella
Vis graf over relationer

PURPOSE: This study aimed to validate a predefined algorithm for osteonecrosis of the jaw (ONJ) among cancer patients in the Danish National Registry of Patients and to assess the nature of clinical information recorded in medical charts of ONJ patients.

METHODS: We identified potential ONJ cases recorded in 2005-2010 among cancer patients at the hospital Departments of Oral and Maxillofacial Surgery (DOMS) in three Danish regions, using a set of codes from the International Classification of Diseases, 10th revision (ICD-10). We abstracted DOMS charts of the potential cases, had the ONJ status adjudicated by an expert ONJ adjudication committee (ONJAC), and computed positive predictive values. For patients with ONJAC-confirmed ONJ, we abstracted the charts for information on ONJ clinical course. Sensitivity of the algorithm was computed using a separate sample of 101 known ONJ cases accrued in 2005-2011.

RESULTS: We identified 212 potential ONJ cases, of which 197 (93%) had charts available for abstraction. Eighty-three potential cases were confirmed by ONJAC, with a positive predictive value of 42% (95% confidence interval [CI] 35%-49%). DOMS charts of these 83 cases contained complete information on ONJ clinical course. Information about antiresorptive treatment was recorded for 84% of the patients. Among the 101 known ONJ cases, 74 had at least one prespecified ICD-10 code recorded in the Danish National Registry of Patients within ±90 days of the ONJ diagnosis (sensitivity 73%; 95%CI [64%-81%]).

CONCLUSIONS: The predefined algorithm is not adequate for monitoring ONJ in pharmacovigilance studies. Additional case-finding approaches, coupled with adjudication, are necessary to estimate ONJ incidence accurately.

OriginalsprogEngelsk
TidsskriftPharmacoepidemiology and Drug Safety
Vol/bind24
Udgave nummer7
Sider (fra-til)693-700
Antal sider8
ISSN1053-8569
DOI
StatusUdgivet - jul. 2015

ID: 46231108