Evaluation of a Modified High-Definition Electrode Montage for Transcranial Alternating Current Stimulation (tACS) of Pre-Central Areas

Kirstin-Friederike Heise; Nick Kortzorg; Guilherme Bicalho Saturnino; Hakuei Fujiyama; Koen Cuypers; Axel Thielscher; Stephan P Swinnen

doi:10.1016/j.brs.2016.04.009

Evaluation of a Modified High-Definition Electrode Montage for Transcranial Alternating Current Stimulation (tACS) of Pre-Central Areas

Kirstin-Friederike Heise, Nick Kortzorg, Guilherme Bicalho Saturnino, Hakuei Fujiyama, Koen Cuypers, Axel Thielscher, Stephan P Swinnen

49 Citationer (Scopus)

Abstract

OBJECTIVE: To evaluate a modified electrode montage with respect to its effect on tACS-dependent modulation of corticospinal excitability and discomfort caused by neurosensory side effects accompanying stimulation.

METHODS: In a double-blind cross-over design, the classical electrode montage for primary motor cortex (M1) stimulation (two patch electrodes over M1 and contralateral supraorbital area) was compared with an M1 centre-ring montage. Corticospinal excitability was evaluated before, during, immediately after and 15 minutes after tACS (10 min., 20 Hz vs. 30 s low-frequency transcranial random noise stimulation).

RESULTS: Corticospinal excitability increased significantly during and immediately after tACS with the centre-ring montage. This was not the case with the classical montage or tRNS stimulation. Level of discomfort was rated on average lower with the centre-ring montage.

CONCLUSIONS: In comparison to the classic montage, the M1 centre-ring montage enables a more focal stimulation of the target area and, at the same time, significantly reduces neurosensory side effects, essential for placebo-controlled study designs.

Originalsprog	Engelsk
Tidsskrift	Brain Stimulation
Vol/bind	9
Udgave nummer	5
Sider (fra-til)	700-704
Antal sider	5
ISSN	1935-861X
DOI	https://doi.org/10.1016/j.brs.2016.04.009
Status	Udgivet - 2016

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10.1016/j.brs.2016.04.009

Citationsformater

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title = "Evaluation of a Modified High-Definition Electrode Montage for Transcranial Alternating Current Stimulation (tACS) of Pre-Central Areas",

abstract = "OBJECTIVE: To evaluate a modified electrode montage with respect to its effect on tACS-dependent modulation of corticospinal excitability and discomfort caused by neurosensory side effects accompanying stimulation.METHODS: In a double-blind cross-over design, the classical electrode montage for primary motor cortex (M1) stimulation (two patch electrodes over M1 and contralateral supraorbital area) was compared with an M1 centre-ring montage. Corticospinal excitability was evaluated before, during, immediately after and 15 minutes after tACS (10 min., 20 Hz vs. 30 s low-frequency transcranial random noise stimulation).RESULTS: Corticospinal excitability increased significantly during and immediately after tACS with the centre-ring montage. This was not the case with the classical montage or tRNS stimulation. Level of discomfort was rated on average lower with the centre-ring montage.CONCLUSIONS: In comparison to the classic montage, the M1 centre-ring montage enables a more focal stimulation of the target area and, at the same time, significantly reduces neurosensory side effects, essential for placebo-controlled study designs.",

author = "Kirstin-Friederike Heise and Nick Kortzorg and Saturnino, {Guilherme Bicalho} and Hakuei Fujiyama and Koen Cuypers and Axel Thielscher and Swinnen, {Stephan P}",

year = "2016",

doi = "10.1016/j.brs.2016.04.009",

language = "English",

volume = "9",

pages = "700--704",

journal = "Brain Stimulation",

issn = "1935-861X",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Evaluation of a Modified High-Definition Electrode Montage for Transcranial Alternating Current Stimulation (tACS) of Pre-Central Areas

AU - Heise, Kirstin-Friederike

AU - Kortzorg, Nick

AU - Saturnino, Guilherme Bicalho

AU - Fujiyama, Hakuei

AU - Cuypers, Koen

AU - Thielscher, Axel

AU - Swinnen, Stephan P

PY - 2016

Y1 - 2016

N2 - OBJECTIVE: To evaluate a modified electrode montage with respect to its effect on tACS-dependent modulation of corticospinal excitability and discomfort caused by neurosensory side effects accompanying stimulation.METHODS: In a double-blind cross-over design, the classical electrode montage for primary motor cortex (M1) stimulation (two patch electrodes over M1 and contralateral supraorbital area) was compared with an M1 centre-ring montage. Corticospinal excitability was evaluated before, during, immediately after and 15 minutes after tACS (10 min., 20 Hz vs. 30 s low-frequency transcranial random noise stimulation).RESULTS: Corticospinal excitability increased significantly during and immediately after tACS with the centre-ring montage. This was not the case with the classical montage or tRNS stimulation. Level of discomfort was rated on average lower with the centre-ring montage.CONCLUSIONS: In comparison to the classic montage, the M1 centre-ring montage enables a more focal stimulation of the target area and, at the same time, significantly reduces neurosensory side effects, essential for placebo-controlled study designs.

AB - OBJECTIVE: To evaluate a modified electrode montage with respect to its effect on tACS-dependent modulation of corticospinal excitability and discomfort caused by neurosensory side effects accompanying stimulation.METHODS: In a double-blind cross-over design, the classical electrode montage for primary motor cortex (M1) stimulation (two patch electrodes over M1 and contralateral supraorbital area) was compared with an M1 centre-ring montage. Corticospinal excitability was evaluated before, during, immediately after and 15 minutes after tACS (10 min., 20 Hz vs. 30 s low-frequency transcranial random noise stimulation).RESULTS: Corticospinal excitability increased significantly during and immediately after tACS with the centre-ring montage. This was not the case with the classical montage or tRNS stimulation. Level of discomfort was rated on average lower with the centre-ring montage.CONCLUSIONS: In comparison to the classic montage, the M1 centre-ring montage enables a more focal stimulation of the target area and, at the same time, significantly reduces neurosensory side effects, essential for placebo-controlled study designs.

U2 - 10.1016/j.brs.2016.04.009

DO - 10.1016/j.brs.2016.04.009

M3 - Journal article

C2 - 27160465

SN - 1935-861X

VL - 9

SP - 700

EP - 704

JO - Brain Stimulation

JF - Brain Stimulation

IS - 5

ER -

Evaluation of a Modified High-Definition Electrode Montage for Transcranial Alternating Current Stimulation (tACS) of Pre-Central Areas

Abstract

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