Evaluation of a 99Tcm bound brain scanning agent for single photon emission computed tomography

A R Andersen; S G Hasselbalch; O B Paulson; N A Lassen; K Kristensen; R D Neirinckx

Evaluation of a 99Tcm bound brain scanning agent for single photon emission computed tomography

A R Andersen, S G Hasselbalch, O B Paulson, N A Lassen, K Kristensen, R D Neirinckx

2 Citationer (Scopus)

Abstract

D,L HM-PAO-99Tcm (PAO) is a lipophilic tracer complex which is avidly taken up by the brain. We have compared the regional distribution of PAO with regional cerebral blood flow (CBF). CBF was measured by single photon emission computed tomography (SPECT) by Tomomatic 64 after 133Xe inhalation in 41 patients. With the same SPECT the distribution of PAO was measured after intravenous injection. High resolution (HR) and low resolution (LR) studies were performed yielding a resolution of 6-10 mm (HR) and 15-20 mm (LR). PAO images showed close resemblance to 133Xe CBF tomograms. Only 20 per cent of the (decay corrected) brain counts were lost during 24 hours.

Originalsprog	Engelsk
Tidsskrift	Acta radiologica. Supplementum
Vol/bind	369
Sider (fra-til)	456-9
Antal sider	4
ISSN	0365-5954
Status	Udgivet - 1986

Citationsformater

@article{35bbe287711842cba0d89c1191f13c00,

title = "Evaluation of a 99Tcm bound brain scanning agent for single photon emission computed tomography",

abstract = "D,L HM-PAO-99Tcm (PAO) is a lipophilic tracer complex which is avidly taken up by the brain. We have compared the regional distribution of PAO with regional cerebral blood flow (CBF). CBF was measured by single photon emission computed tomography (SPECT) by Tomomatic 64 after 133Xe inhalation in 41 patients. With the same SPECT the distribution of PAO was measured after intravenous injection. High resolution (HR) and low resolution (LR) studies were performed yielding a resolution of 6-10 mm (HR) and 15-20 mm (LR). PAO images showed close resemblance to 133Xe CBF tomograms. Only 20 per cent of the (decay corrected) brain counts were lost during 24 hours.",

keywords = "Brain, Brain Diseases, Cerebrovascular Circulation, Evaluation Studies as Topic, Female, Humans, Middle Aged, Organotechnetium Compounds, Oximes, Technetium Tc 99m Exametazime, Tomography, Emission-Computed, Single-Photon",

author = "Andersen, {A R} and Hasselbalch, {S G} and Paulson, {O B} and Lassen, {N A} and K Kristensen and Neirinckx, {R D}",

year = "1986",

language = "English",

volume = "369",

pages = "456--9",

journal = "Acta radiologica. Supplementum",

issn = "0365-5954",

publisher = "Taylor and Francis Ltd.",

}

TY - JOUR

T1 - Evaluation of a 99Tcm bound brain scanning agent for single photon emission computed tomography

AU - Andersen, A R

AU - Hasselbalch, S G

AU - Paulson, O B

AU - Lassen, N A

AU - Kristensen, K

AU - Neirinckx, R D

PY - 1986

Y1 - 1986

N2 - D,L HM-PAO-99Tcm (PAO) is a lipophilic tracer complex which is avidly taken up by the brain. We have compared the regional distribution of PAO with regional cerebral blood flow (CBF). CBF was measured by single photon emission computed tomography (SPECT) by Tomomatic 64 after 133Xe inhalation in 41 patients. With the same SPECT the distribution of PAO was measured after intravenous injection. High resolution (HR) and low resolution (LR) studies were performed yielding a resolution of 6-10 mm (HR) and 15-20 mm (LR). PAO images showed close resemblance to 133Xe CBF tomograms. Only 20 per cent of the (decay corrected) brain counts were lost during 24 hours.

AB - D,L HM-PAO-99Tcm (PAO) is a lipophilic tracer complex which is avidly taken up by the brain. We have compared the regional distribution of PAO with regional cerebral blood flow (CBF). CBF was measured by single photon emission computed tomography (SPECT) by Tomomatic 64 after 133Xe inhalation in 41 patients. With the same SPECT the distribution of PAO was measured after intravenous injection. High resolution (HR) and low resolution (LR) studies were performed yielding a resolution of 6-10 mm (HR) and 15-20 mm (LR). PAO images showed close resemblance to 133Xe CBF tomograms. Only 20 per cent of the (decay corrected) brain counts were lost during 24 hours.

KW - Brain

KW - Brain Diseases

KW - Cerebrovascular Circulation

KW - Evaluation Studies as Topic

KW - Female

KW - Humans

KW - Middle Aged

KW - Organotechnetium Compounds

KW - Oximes

KW - Technetium Tc 99m Exametazime

KW - Tomography, Emission-Computed, Single-Photon

M3 - Journal article

C2 - 2980525

SN - 0365-5954

VL - 369

SP - 456

EP - 459

JO - Acta radiologica. Supplementum

JF - Acta radiologica. Supplementum

ER -

Evaluation of a 99Tcm bound brain scanning agent for single photon emission computed tomography

Abstract

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