Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results from the treatment of mucosal cancers

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Plaschke, CC, Bertino, G, McCaul, JA, Grau, JJ, de Bree, R, Sersa, G, Occhini, A, Groselj, A, Langdon, C, Heuveling, DA, Cemazar, M, Strojan, P, Leemans, CR, Benazzo, M, De Terlizzi, F, Wessel, I & Gehl, J 2017, 'European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results from the treatment of mucosal cancers', European journal of cancer (Oxford, England : 1990), bind 87, s. 172-181. https://doi.org/10.1016/j.ejca.2017.10.008

APA

Plaschke, C. C., Bertino, G., McCaul, J. A., Grau, J. J., de Bree, R., Sersa, G., Occhini, A., Groselj, A., Langdon, C., Heuveling, D. A., Cemazar, M., Strojan, P., Leemans, C. R., Benazzo, M., De Terlizzi, F., Wessel, I., & Gehl, J. (2017). European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results from the treatment of mucosal cancers. European journal of cancer (Oxford, England : 1990), 87, 172-181. https://doi.org/10.1016/j.ejca.2017.10.008

CBE

Plaschke CC, Bertino G, McCaul JA, Grau JJ, de Bree R, Sersa G, Occhini A, Groselj A, Langdon C, Heuveling DA, Cemazar M, Strojan P, Leemans CR, Benazzo M, De Terlizzi F, Wessel I, Gehl J. 2017. European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results from the treatment of mucosal cancers. European journal of cancer (Oxford, England : 1990). 87:172-181. https://doi.org/10.1016/j.ejca.2017.10.008

MLA

Vancouver

Author

Plaschke, Christina Caroline ; Bertino, Giulia ; McCaul, James A ; Grau, Juan J ; de Bree, Remco ; Sersa, Gregor ; Occhini, Antonio ; Groselj, Ales ; Langdon, Cristobal ; Heuveling, Derrek A ; Cemazar, Maja ; Strojan, Primoz ; Leemans, C Rene ; Benazzo, Marco ; De Terlizzi, Francesca ; Wessel, Irene ; Gehl, Julie. / European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project : Results from the treatment of mucosal cancers. I: European journal of cancer (Oxford, England : 1990). 2017 ; Bind 87. s. 172-181.

Bibtex

@article{59e0e79f932c48e3b4d488950b33ef3e,
title = "European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results from the treatment of mucosal cancers",
abstract = "AIM: Electrochemotherapy is an effective local treatment for cutaneous tumours and metastases. In this prospective trial, six European institutions investigated electrochemotherapy in recurrent, mucosal head and neck tumours.PATIENT AND METHODS: Forty-three patients with recurrent mucosal head and neck tumours and no further curative or reasonably effective palliative treatment options were enrolled and treated with electrochemotherapy. Patients were treated in general anaesthesia using intravenous or local injection of bleomycin followed by delivery of electric pulses to the tumour area. Primary end-point was local tumour response. Secondary end-points were safety and toxicity, overall and progression free survival, and quality-of-life.RESULTS: Thirty-seven patients were evaluable for tumour response, pain score, side-effects and quality of life questionnaires. Six patients were not evaluable due to lost follow-up, disease progression or death before evaluation. Intention to treat analysis revealed an objective response of 56% (complete response 8 (19%), partial response 16 (37%), stable disease 10 (23%), progressive disease 3 (7%), and not evaluable 6 (14%)). Three patients (7%) remained in complete response at 30, 34, and 84 months post-treatment. The treatment procedure was generally well tolerated. Swelling of the mucosa was observed in the first days after treatment. Pain and use of pain medication rose temporarily; fatigue and dysphagia were also noted in the quality of life assessment.CONCLUSION: Electrochemotherapy can be applied to mucosal head and neck recurrent tumours accessible to the procedure with promising objective response, survival and toxicity profile. Attention should be paid to post-treatment swelling and planning of pain medication. These favourable results indicate that electrochemotherapy could play a role in patients with recurrent head and neck cancer.",
keywords = "Aged, Aged, 80 and over, Antibiotics, Antineoplastic, Bleomycin, Carcinoma, Squamous Cell, Disease-Free Survival, Electrochemotherapy, Europe, Female, Head and Neck Neoplasms, Humans, Infusions, Intravenous, Injections, Intralesional, Injections, Intravenous, Intention to Treat Analysis, Kaplan-Meier Estimate, Male, Middle Aged, Mucous Membrane, Neoplasm Recurrence, Local, Prospective Studies, Quality of Life, Time Factors, Treatment Outcome, Clinical Trial, Phase II, Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't",
author = "Plaschke, {Christina Caroline} and Giulia Bertino and McCaul, {James A} and Grau, {Juan J} and {de Bree}, Remco and Gregor Sersa and Antonio Occhini and Ales Groselj and Cristobal Langdon and Heuveling, {Derrek A} and Maja Cemazar and Primoz Strojan and Leemans, {C Rene} and Marco Benazzo and {De Terlizzi}, Francesca and Irene Wessel and Julie Gehl",
note = "Copyright {\textcopyright} 2017 Elsevier Ltd. All rights reserved.",
year = "2017",
month = dec,
doi = "10.1016/j.ejca.2017.10.008",
language = "English",
volume = "87",
pages = "172--181",
journal = "European Journal of Cancer, Supplement",
issn = "0959-8049",
publisher = "Pergamon",

}

RIS

TY - JOUR

T1 - European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project

T2 - Results from the treatment of mucosal cancers

AU - Plaschke, Christina Caroline

AU - Bertino, Giulia

AU - McCaul, James A

AU - Grau, Juan J

AU - de Bree, Remco

AU - Sersa, Gregor

AU - Occhini, Antonio

AU - Groselj, Ales

AU - Langdon, Cristobal

AU - Heuveling, Derrek A

AU - Cemazar, Maja

AU - Strojan, Primoz

AU - Leemans, C Rene

AU - Benazzo, Marco

AU - De Terlizzi, Francesca

AU - Wessel, Irene

AU - Gehl, Julie

N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.

PY - 2017/12

Y1 - 2017/12

N2 - AIM: Electrochemotherapy is an effective local treatment for cutaneous tumours and metastases. In this prospective trial, six European institutions investigated electrochemotherapy in recurrent, mucosal head and neck tumours.PATIENT AND METHODS: Forty-three patients with recurrent mucosal head and neck tumours and no further curative or reasonably effective palliative treatment options were enrolled and treated with electrochemotherapy. Patients were treated in general anaesthesia using intravenous or local injection of bleomycin followed by delivery of electric pulses to the tumour area. Primary end-point was local tumour response. Secondary end-points were safety and toxicity, overall and progression free survival, and quality-of-life.RESULTS: Thirty-seven patients were evaluable for tumour response, pain score, side-effects and quality of life questionnaires. Six patients were not evaluable due to lost follow-up, disease progression or death before evaluation. Intention to treat analysis revealed an objective response of 56% (complete response 8 (19%), partial response 16 (37%), stable disease 10 (23%), progressive disease 3 (7%), and not evaluable 6 (14%)). Three patients (7%) remained in complete response at 30, 34, and 84 months post-treatment. The treatment procedure was generally well tolerated. Swelling of the mucosa was observed in the first days after treatment. Pain and use of pain medication rose temporarily; fatigue and dysphagia were also noted in the quality of life assessment.CONCLUSION: Electrochemotherapy can be applied to mucosal head and neck recurrent tumours accessible to the procedure with promising objective response, survival and toxicity profile. Attention should be paid to post-treatment swelling and planning of pain medication. These favourable results indicate that electrochemotherapy could play a role in patients with recurrent head and neck cancer.

AB - AIM: Electrochemotherapy is an effective local treatment for cutaneous tumours and metastases. In this prospective trial, six European institutions investigated electrochemotherapy in recurrent, mucosal head and neck tumours.PATIENT AND METHODS: Forty-three patients with recurrent mucosal head and neck tumours and no further curative or reasonably effective palliative treatment options were enrolled and treated with electrochemotherapy. Patients were treated in general anaesthesia using intravenous or local injection of bleomycin followed by delivery of electric pulses to the tumour area. Primary end-point was local tumour response. Secondary end-points were safety and toxicity, overall and progression free survival, and quality-of-life.RESULTS: Thirty-seven patients were evaluable for tumour response, pain score, side-effects and quality of life questionnaires. Six patients were not evaluable due to lost follow-up, disease progression or death before evaluation. Intention to treat analysis revealed an objective response of 56% (complete response 8 (19%), partial response 16 (37%), stable disease 10 (23%), progressive disease 3 (7%), and not evaluable 6 (14%)). Three patients (7%) remained in complete response at 30, 34, and 84 months post-treatment. The treatment procedure was generally well tolerated. Swelling of the mucosa was observed in the first days after treatment. Pain and use of pain medication rose temporarily; fatigue and dysphagia were also noted in the quality of life assessment.CONCLUSION: Electrochemotherapy can be applied to mucosal head and neck recurrent tumours accessible to the procedure with promising objective response, survival and toxicity profile. Attention should be paid to post-treatment swelling and planning of pain medication. These favourable results indicate that electrochemotherapy could play a role in patients with recurrent head and neck cancer.

KW - Aged

KW - Aged, 80 and over

KW - Antibiotics, Antineoplastic

KW - Bleomycin

KW - Carcinoma, Squamous Cell

KW - Disease-Free Survival

KW - Electrochemotherapy

KW - Europe

KW - Female

KW - Head and Neck Neoplasms

KW - Humans

KW - Infusions, Intravenous

KW - Injections, Intralesional

KW - Injections, Intravenous

KW - Intention to Treat Analysis

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Mucous Membrane

KW - Neoplasm Recurrence, Local

KW - Prospective Studies

KW - Quality of Life

KW - Time Factors

KW - Treatment Outcome

KW - Clinical Trial, Phase II

KW - Journal Article

KW - Multicenter Study

KW - Observational Study

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.ejca.2017.10.008

DO - 10.1016/j.ejca.2017.10.008

M3 - Journal article

C2 - 29156298

VL - 87

SP - 172

EP - 181

JO - European Journal of Cancer, Supplement

JF - European Journal of Cancer, Supplement

SN - 0959-8049

ER -

ID: 52573372