European multicentre database of healthy controls for [(123)I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis

Andrea Varrone, John C Dickson, Livia Tossici-Bolt, Terez Sera, Susanne Asenbaum, Jan Booij, Ozlem L Kapucu, Andreas Kluge, Gitte M Knudsen, Pierre Malick Koulibaly, Flavio Nobili, Marco Pagani, Osama Sabri, Thierry Vander Borght, Koen Van Laere, Klaus Tatsch

200 Citationer (Scopus)

Abstract

Dopamine transporter (DAT) imaging with [(123)I]FP-CIT (DaTSCAN) is an established diagnostic tool in parkinsonism and dementia. Although qualitative assessment criteria are available, DAT quantification is important for research and for completion of a diagnostic evaluation. One critical aspect of quantification is the availability of normative data, considering possible age and gender effects on DAT availability. The aim of the European Normal Control Database of DaTSCAN (ENC-DAT) study was to generate a large database of [(123)I]FP-CIT SPECT scans in healthy controls.
OriginalsprogEngelsk
TidsskriftEuropean Journal of Nuclear Medicine and Molecular Imaging
Vol/bind40
Udgave nummer2
Sider (fra-til)213-27
Antal sider15
ISSN1619-7070
DOI
StatusUdgivet - 2013

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