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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Etiology of Placental Plasmodium falciparum Malaria in African Women

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. A vaccine targeted specifically to prevent cerebral malaria - is there hope?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Michael F Ofori
  • Helena Lamptey
  • Emmanuel K Dickson
  • Eric Kyei-Baafour
  • Lars Hviid
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Plasmodium falciparum parasites causing placental malaria express the VAR2CSA type of the clonally variant antigen family erythrocyte membrane protein 1 (PfEMP1). This enables evasion of preexisting immunity and results in placental accumulation of infected erythrocytes. We present data on seasonal variation in levels of VAR2CSA-specific immunoglobulin G (IgG) and IgG specific for a placental malaria-unrelated PfEMP1 protein among Ghanaian women at their first antenatal visit. Our results indicate that placental malaria does not require recent exposure to infected mosquitoes, in contrast to malaria in general. This has implications for the impact of insecticide-treated bed nets on placental malaria incidence and for antenatal care in woman with preexisting immunity.

OriginalsprogEngelsk
TidsskriftThe Journal of infectious diseases
Vol/bind218
Udgave nummer2
Sider (fra-til)277-281
Antal sider5
ISSN0022-1899
DOI
StatusUdgivet - 20 jun. 2018

ID: 56396089