TY - JOUR
T1 - Etiology and Outcome of Adult and Pediatric Acute Liver Failure in Europe
AU - Lenz, Dominic
AU - Jørgensen, Marianne Hørby
AU - Kelly, Deirdre
AU - Cardinale, Vincenzo
AU - Geerts, Anja
AU - Gonçalves Costa, Isabel
AU - Fichtner, Alexander
AU - Garbade, Sven F
AU - Hegen, Bianca
AU - Hilberath, Johannes
AU - de Kleine, Ruben
AU - Kupčinskas, Limas
AU - McLin, Valérie
AU - Niesert, Moritz
AU - Prado Gonzalez, Veronica
AU - Sturm, Ekkehard
AU - Staufner, Christian
AU - Tjwa, Eric
AU - Willemse, José
AU - Zecher, Britta F
AU - Larsen, Fin Stolze
AU - Sebode, Marcial
AU - Ytting, Henriette
N1 - Copyright © 2023 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
PY - 2023/7/1
Y1 - 2023/7/1
N2 - Acute liver failure (ALF) is rare but life-threatening. Common causes include intoxications, infections, and metabolic disorders. Indeterminate etiology is still frequent. No systematic data on incidence, causes, and outcome of ALF across Europe are available. Via an online survey we reached out to European Reference Network Centers on rare liver diseases. Numbers and etiology of ALF cases during 2020 were retrieved and diagnostic and treatment availabilities assessed. In total, 455 cases (306 adult, 149 pediatric) were reported from 36 centers from 20 countries. Intoxication was the most common cause in adult and pediatric care. The number of cases with indeterminate etiology is low. Diagnostic tools and specific treatment options are broadly available within this network. This is the first approach to report on etiology and outcome of ALF in the pediatric and adult population in Europe. High diagnostic yield and standard of care reflects the expert status of involved centers.
AB - Acute liver failure (ALF) is rare but life-threatening. Common causes include intoxications, infections, and metabolic disorders. Indeterminate etiology is still frequent. No systematic data on incidence, causes, and outcome of ALF across Europe are available. Via an online survey we reached out to European Reference Network Centers on rare liver diseases. Numbers and etiology of ALF cases during 2020 were retrieved and diagnostic and treatment availabilities assessed. In total, 455 cases (306 adult, 149 pediatric) were reported from 36 centers from 20 countries. Intoxication was the most common cause in adult and pediatric care. The number of cases with indeterminate etiology is low. Diagnostic tools and specific treatment options are broadly available within this network. This is the first approach to report on etiology and outcome of ALF in the pediatric and adult population in Europe. High diagnostic yield and standard of care reflects the expert status of involved centers.
UR - http://www.scopus.com/inward/record.url?scp=85163509620&partnerID=8YFLogxK
U2 - 10.1097/MPG.0000000000003777
DO - 10.1097/MPG.0000000000003777
M3 - Journal article
C2 - 36930963
SN - 0277-2116
VL - 77
SP - 115
EP - 120
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
IS - 1
ER -