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Ethnic differences in inflammatory bowel disease: Results from the United Kingdom inception cohort epidemiology study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Ravi Misra
  • Jimmy Limdi
  • Rachel Cooney
  • Samia Sakuma
  • Matthew Brookes
  • Edward Fogden
  • Sanjeev Pattni
  • Naveen Sharma
  • Tariq Iqbal
  • Pia Munkholm
  • Johan Burisch
  • Naila Arebi
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BACKGROUND: The current epidemiology of inflammatory bowel disease (IBD) in the multi-ethnic United Kingdom is unknown. The last incidence study in the United Kingdom was carried out over 20 years ago.

AIM: To describe the incidence and phenotype of IBD and distribution within ethnic groups.

METHODS: Adult patients (> 16 years) with newly diagnosed IBD (fulfilling Copenhagen diagnostic criteria) were prospectively recruited over one year in 5 urban catchment areas with high South Asian population. Patient demographics, ethnic codes, disease phenotype (Montreal classification), disease activity and treatment within 3 months of diagnosis were recorded onto the Epicom database.

RESULTS: Across a population of 2271406 adults, 339 adult patients were diagnosed with IBD over one year: 218 with ulcerative colitis (UC, 64.3%), 115 with Crohn's disease (CD, 33.9%) and 6 with IBD unclassified (1.8%). The crude incidence of IBD, UC and CD was 17.0/100000, 11.3/100000 and 5.3/100000 respectively. The age adjusted incidence of IBD and UC were significantly higher in the Indian group (25.2/100000 and 20.5/100000) compared to White European (14.9/100000, P = 0.009 and 8.2/100000, P < 0.001) and Pakistani groups (14.9/100000, P = 0.001 and 11.2/100000, P = 0.007). The Indian group were significantly more likely to have extensive disease than White Europeans (52.7% vs 41.7%, P = 0.031). There was no significant difference in time to diagnosis, disease activity and treatment.

CONCLUSION: This is the only prospective study to report the incidence of IBD in an ethnically diverse United Kingdom population. The Indian ethnic group showed the highest age-adjusted incidence of UC (20.5/100000). Further studies on dietary, microbial and metabolic factors that might explain these findings in UC are underway.

OriginalsprogEngelsk
TidsskriftWorld Journal of Gastroenterology
Vol/bind25
Udgave nummer40
Sider (fra-til)6145-6157
Antal sider13
ISSN1007-9327
DOI
StatusUdgivet - 2019

Bibliografisk note

©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

ID: 58358113