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Region Hovedstaden - en del af Københavns Universitetshospital
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Estimation of allele frequency and association mapping using next-generation sequencing data

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Su Yeon Kim
  • Kirk E Lohmueller
  • Anders Albrechtsen
  • Yingrui Li
  • Thorfinn Korneliussen
  • Geng Tian
  • Niels Grarup
  • Tao Jiang
  • Gitte Andersen
  • Daniel Rinse Witte
  • Torben Jorgensen
  • Torben Hansen
  • Oluf Pedersen
  • Jun Wang
  • Rasmus Nielsen
Vis graf over relationer
Estimation of allele frequency is of fundamental importance in population genetic analyses and in association mapping. In most studies using next-generation sequencing, a cost effective approach is to use medium or low-coverage data (e.g., <15X). However, SNP calling and allele frequency estimation in such studies is associated with substantial statistical uncertainty because of varying coverage and high error rates.
OriginalsprogEngelsk
TidsskriftB M C Bioinformatics
Vol/bind12
Sider (fra-til)231
ISSN1471-2105
DOI
StatusUdgivet - 2011

ID: 34686186