@article{56475f07e9454438896bfb66c0e7de4b,
title = "Estimation of allele frequency and association mapping using next-generation sequencing data",
abstract = "Estimation of allele frequency is of fundamental importance in population genetic analyses and in association mapping. In most studies using next-generation sequencing, a cost effective approach is to use medium or low-coverage data (e.g., <15X). However, SNP calling and allele frequency estimation in such studies is associated with substantial statistical uncertainty because of varying coverage and high error rates.",
keywords = "Gene Frequency, Genetics, Population, Genotype, High-Throughput Nucleotide Sequencing, Humans, Likelihood Functions, Polymorphism, Single Nucleotide, Sequence Analysis, DNA",
author = "Kim, {Su Yeon} and Lohmueller, {Kirk E} and Anders Albrechtsen and Yingrui Li and Thorfinn Korneliussen and Geng Tian and Niels Grarup and Tao Jiang and Gitte Andersen and Witte, {Daniel Rinse} and Torben Jorgensen and Torben Hansen and Oluf Pedersen and Jun Wang and Rasmus Nielsen",
year = "2011",
doi = "10.1186/1471-2105-12-231",
language = "English",
volume = "12",
pages = "231",
journal = "B M C Bioinformatics",
issn = "1471-2105",
publisher = "BioMed Central Ltd",
}