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Region Hovedstaden - en del af Københavns Universitetshospital
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Estimating Renal Function Following Lung Transplantation

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DOI

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Vis graf over relationer

Background: Patients undergoing lung transplantation (LTx) experience a rapid decline in glomerular filtration rate (GFR) in the acute postoperative period. However, no prospective longitudinal studies directly comparing the performance of equations for estimating GFR in this patient population currently exist. Methods: In total, 32 patients undergoing LTx met the study criteria. At pre-LTx and 1-, 3-, and 12-weeks post-LTx, GFR was determined by51 Cr-EDTA and by equations for estimating GFR based on plasma (P)-Creatinine, P-Cystatin C, or a combination of both. Results: Measured GFR declined from 98.0 mL/min/1.73 m2 at pre-LTx to 54.1 mL/min/1.73 m2 at 12-weeks post-LTx. Equations based on P-Creatinine underestimated GFR decline after LTx, whereas equations based on P-Cystatin C overestimated this decline. Overall, the 2021 CKD-EPI combination equation had the lowest bias and highest precision at both pre-LTx and post-LTx. Conclusions: Caution must be applied when interpreting renal function based on equations for estimating GFR in the acute postoperative period following LTx. Simplified methods for measuring GFR may allow for more widespread use of measured GFR in this vulnerable patient population.

OriginalsprogEngelsk
Artikelnummer1496
TidsskriftJournal of Clinical Medicine
Vol/bind11
Udgave nummer6
ISSN2077-0383
DOI
StatusUdgivet - 9 mar. 2022

Bibliografisk note

Funding Information:
Funding: M.H. was supported by an unrestricted grant from the Helen and Ejnar Bjørnow Foundation and a grant from the Lundbeck Foundation (R187-2015-2148). M.B.H. was supported by a postdoctoral fellowship from The Capital Region’s Research Foundation for Health Research, Denmark (A6882).

Funding Information:
M.H. was supported by an unrestricted grant from the Helen and Ejnar Bj?rnow Foundation and a grant from the Lundbeck Foundation (R187-2015-2148). M.B.H. was supported by a postdoctoral fellowship from The Capital Region?s Research Foundation for Health Research, Denmark (A6882).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

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