Estimating prevalence of accumulated HIV-1 drug resistance in a cohort of patients on antiretroviral therapy

Wendy P Bannister; Alessandro Cozzi-Lepri; Jesper Kjær; Bonaventura Clotet; Adriano Lazzarin; Jean-Paul Viard; Gitte Kronborg; Dan Duiculescu; Marek Beniowski; Ladislav Machala; Andrew Phillips; EuroSIDA group

doi:10.1093/jac/dkr006

Estimating prevalence of accumulated HIV-1 drug resistance in a cohort of patients on antiretroviral therapy

Wendy P Bannister, Alessandro Cozzi-Lepri, Jesper Kjær, Bonaventura Clotet, Adriano Lazzarin, Jean-Paul Viard, Gitte Kronborg, Dan Duiculescu, Marek Beniowski, Ladislav Machala, Andrew Phillips, EuroSIDA group

Infektionsmedicinsk Afdeling

14 Citationer (Scopus)

Abstract

Estimating the prevalence of accumulated HIV drug resistance in patients receiving antiretroviral therapy (ART) is difficult due to lack of resistance testing at all occasions of virological failure and in patients with undetectable viral load. A method to estimate this for 6498 EuroSIDA patients who were under follow-up on ART at 1 July 2008 was therefore developed by imputing data on patients with no prior resistance test results, based on the probability of detecting resistance in tested patients with similar profiles.

Originalsprog	Engelsk
Tidsskrift	Journal of Antimicrobial Chemotherapy
Vol/bind	66
Udgave nummer	4
Sider (fra-til)	901-11
Antal sider	11
ISSN	0305-7453
DOI	https://doi.org/10.1093/jac/dkr006
Status	Udgivet - 2011

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10.1093/jac/dkr006

Citationsformater

Bannister, W. P., Cozzi-Lepri, A., Kjær, J., Clotet, B., Lazzarin, A., Viard, J.-P., Kronborg, G., Duiculescu, D., Beniowski, M., Machala, L., Phillips, A., & EuroSIDA group (2011). Estimating prevalence of accumulated HIV-1 drug resistance in a cohort of patients on antiretroviral therapy. Journal of Antimicrobial Chemotherapy, 66(4), 901-11. https://doi.org/10.1093/jac/dkr006

Bannister, WP, Cozzi-Lepri, A, Kjær, J, Clotet, B, Lazzarin, A, Viard, J-P, Kronborg, G, Duiculescu, D, Beniowski, M, Machala, L, Phillips, A & EuroSIDA group 2011, 'Estimating prevalence of accumulated HIV-1 drug resistance in a cohort of patients on antiretroviral therapy', Journal of Antimicrobial Chemotherapy, bind 66, nr. 4, s. 901-11. https://doi.org/10.1093/jac/dkr006

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abstract = "Estimating the prevalence of accumulated HIV drug resistance in patients receiving antiretroviral therapy (ART) is difficult due to lack of resistance testing at all occasions of virological failure and in patients with undetectable viral load. A method to estimate this for 6498 EuroSIDA patients who were under follow-up on ART at 1 July 2008 was therefore developed by imputing data on patients with no prior resistance test results, based on the probability of detecting resistance in tested patients with similar profiles.",

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AU - Cozzi-Lepri, Alessandro

AU - Kjær, Jesper

AU - Clotet, Bonaventura

AU - Lazzarin, Adriano

AU - Viard, Jean-Paul

AU - Kronborg, Gitte

AU - Duiculescu, Dan

AU - Beniowski, Marek

AU - Machala, Ladislav

AU - Phillips, Andrew

AU - EuroSIDA group

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KW - Adult

KW - Anti-HIV Agents

KW - Antiretroviral Therapy, Highly Active

KW - Drug Resistance, Viral

KW - Europe

KW - Female

KW - Genotype

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Male

KW - Middle Aged

KW - Mutation

KW - Prevalence

KW - RNA, Viral

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DO - 10.1093/jac/dkr006

M3 - Journal article

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JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

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ER -

Estimating prevalence of accumulated HIV-1 drug resistance in a cohort of patients on antiretroviral therapy

Abstract

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