Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres

D M Sørensen; H Bostock; A Abrahao; A Alaamel; H C Alaydin; M Ballegaard; E Boran; B Cengiz; M de Carvalho; Ø Dunker; A Fuglsang-Frederiksen; C C Graffe; K E Jones; M Kallio; S Kalra; C Krarup; T Krøigård; R Liguori; T Lupescu; S Maitland; J M Matamala; M Moldovan; J Moreno-Roco; K B Nilsen; L Phung; M O Santos; A C Themistocleous; H Uysal; V Vacchiano; R G Whittaker; L Zinman; H Tankisi

doi:10.1016/j.clinph.2023.04.008

Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres

D M Sørensen, H Bostock, A Abrahao, A Alaamel, H C Alaydin, M Ballegaard, E Boran, B Cengiz, M de Carvalho, Ø Dunker, A Fuglsang-Frederiksen, C C Graffe, K E Jones, M Kallio, S Kalra, C Krarup, T Krøigård, R Liguori, T Lupescu, S MaitlandJ M Matamala, M Moldovan, J Moreno-Roco, K B Nilsen, L Phung, M O Santos, A C Themistocleous, H Uysal, V Vacchiano, R G Whittaker, L Zinman, H Tankisi^*

^*Corresponding author af dette arbejde

Afdeling for Hjerne- og Nerveundersøgelser

Abstract

OBJECTIVE: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans.

METHODS: Fifteen groups in 9 countries recorded CMAP scans twice, 1-2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP.

RESULTS: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA.

CONCLUSIONS: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects.

SIGNIFICANCE: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans.

Originalsprog	Engelsk
Tidsskrift	Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Vol/bind	151
Sider (fra-til)	92-99
Antal sider	8
ISSN	1388-2457
DOI	https://doi.org/10.1016/j.clinph.2023.04.008
Status	Udgivet - jul. 2023

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10.1016/j.clinph.2023.04.008

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Sørensen, D. M., Bostock, H., Abrahao, A., Alaamel, A., Alaydin, H. C., Ballegaard, M., Boran, E., Cengiz, B., de Carvalho, M., Dunker, Ø., Fuglsang-Frederiksen, A., Graffe, C. C., Jones, K. E., Kallio, M., Kalra, S., Krarup, C., Krøigård, T., Liguori, R., Lupescu, T., ... Tankisi, H. (2023). Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 151, 92-99. https://doi.org/10.1016/j.clinph.2023.04.008

Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres. / Sørensen, D M; Bostock, H; Abrahao, A et al.
I: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, Bind 151, 07.2023, s. 92-99.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Sørensen, DM, Bostock, H, Abrahao, A, Alaamel, A, Alaydin, HC, Ballegaard, M, Boran, E, Cengiz, B, de Carvalho, M, Dunker, Ø, Fuglsang-Frederiksen, A, Graffe, CC, Jones, KE, Kallio, M, Kalra, S, Krarup, C, Krøigård, T, Liguori, R, Lupescu, T, Maitland, S, Matamala, JM, Moldovan, M, Moreno-Roco, J, Nilsen, KB, Phung, L, Santos, MO, Themistocleous, AC, Uysal, H, Vacchiano, V, Whittaker, RG, Zinman, L & Tankisi, H 2023, 'Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres', Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, bind 151, s. 92-99. https://doi.org/10.1016/j.clinph.2023.04.008

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title = "Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres",

abstract = "OBJECTIVE: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans.METHODS: Fifteen groups in 9 countries recorded CMAP scans twice, 1-2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP.RESULTS: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA.CONCLUSIONS: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects.SIGNIFICANCE: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans.",

author = "S{\o}rensen, {D M} and H Bostock and A Abrahao and A Alaamel and Alaydin, {H C} and M Ballegaard and E Boran and B Cengiz and {de Carvalho}, M and {\O} Dunker and A Fuglsang-Frederiksen and Graffe, {C C} and Jones, {K E} and M Kallio and S Kalra and C Krarup and T Kr{\o}ig{\aa}rd and R Liguori and T Lupescu and S Maitland and Matamala, {J M} and M Moldovan and J Moreno-Roco and Nilsen, {K B} and L Phung and Santos, {M O} and Themistocleous, {A C} and H Uysal and V Vacchiano and Whittaker, {R G} and L Zinman and H Tankisi",

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year = "2023",

month = jul,

doi = "10.1016/j.clinph.2023.04.008",

language = "English",

volume = "151",

pages = "92--99",

journal = "Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology",

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T1 - Estimating motor unit numbers from a CMAP scan

T2 - Repeatability study on three muscles at 15 centres

AU - Sørensen, D M

AU - Bostock, H

AU - Abrahao, A

AU - Alaamel, A

AU - Alaydin, H C

AU - Ballegaard, M

AU - Boran, E

AU - Cengiz, B

AU - de Carvalho, M

AU - Dunker, Ø

AU - Fuglsang-Frederiksen, A

AU - Graffe, C C

AU - Jones, K E

AU - Kallio, M

AU - Kalra, S

AU - Krarup, C

AU - Krøigård, T

AU - Liguori, R

AU - Lupescu, T

AU - Maitland, S

AU - Matamala, J M

AU - Moldovan, M

AU - Moreno-Roco, J

AU - Nilsen, K B

AU - Phung, L

AU - Santos, M O

AU - Themistocleous, A C

AU - Uysal, H

AU - Vacchiano, V

AU - Whittaker, R G

AU - Zinman, L

AU - Tankisi, H

PY - 2023/7

Y1 - 2023/7

N2 - OBJECTIVE: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans.METHODS: Fifteen groups in 9 countries recorded CMAP scans twice, 1-2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP.RESULTS: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA.CONCLUSIONS: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects.SIGNIFICANCE: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans.

AB - OBJECTIVE: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans.METHODS: Fifteen groups in 9 countries recorded CMAP scans twice, 1-2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP.RESULTS: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA.CONCLUSIONS: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects.SIGNIFICANCE: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans.

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U2 - 10.1016/j.clinph.2023.04.008

DO - 10.1016/j.clinph.2023.04.008

M3 - Journal article

C2 - 37236129

SN - 1388-2457

VL - 151

SP - 92

EP - 99

JO - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

ER -

Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres

Abstract

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