Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Establishing a hepatitis C continuum of care among HIV/hepatitis C virus-coinfected individuals in EuroSIDA

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. HIV infection is independently associated with a higher concentration of alpha-1 antitrypsin

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The extent of B-cell activation and dysfunction preceding lymphoma development in HIV-positive people

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The HepHIV 2017 Conference in Malta: joining forces for the earlier diagnosis of HIV and viral hepatitis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. "Risk of de novo or secondary cancer after solid organ or allogeneic haematopoietic stem cell transplantation"

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Prevalence and risk factors of prolonged QT interval and electrocardiographic abnormalities in persons living with HIV

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Syphilitic hepatitis and neurosyphilis: an observational study of Danish HIV-infected individuals during a 13-year period

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • EuroSIDA study group
Vis graf over relationer

OBJECTIVES: The aim of the study was to establish a methodology for evaluating the hepatitis C continuum of care in HIV/hepatitis C virus (HCV)-coinfected individuals and to characterize the continuum in Europe on 1 January 2015, prior to widespread access to direct-acting antiviral (DAA) therapy.

METHODS: Stages included in the continuum were as follows: anti-HCV antibody positive, HCV RNA tested, currently HCV RNA positive, ever HCV RNA positive, ever received HCV treatment, completed HCV treatment, follow-up HCV RNA test, and cure. Sustained virological response (SVR) could only be assessed for those with a follow-up HCV RNA test and was defined as a negative HCV RNA result measured > 12 or 24 weeks after stopping treatment.

RESULTS: Numbers and percentages for the stages of the HCV continuum of care were as follows: anti-HCV positive (n = 5173), HCV RNA tested (4207 of 5173; 81.3%), currently HCV RNA positive (3179 of 5173; 61.5%), ever HCV RNA positive (n = 3876), initiated HCV treatment (1693 of 3876; 43.7%), completed HCV treatment (1598 of 3876; 41.2%), follow-up HCV RNA test to allow SVR assessment (1195 of 3876; 30.8%), and cure (629 of 3876; 16.2%). The proportion that achieved SVR was 52.6% (629 of 1195). There were significant differences between regions at each stage of the continuum (P < 0.0001).

CONCLUSIONS: In the proposed HCV continuum of care for HIV/HCV-coinfected individuals, we found major gaps at all stages, with almost 20% of anti-HCV-positive individuals having no documented HCV RNA test and a low proportion achieving SVR, in the pre-DAA era.

OriginalsprogEngelsk
TidsskriftHIV Medicine
Vol/bind20
Udgave nummer4
Sider (fra-til)264-273
Antal sider10
ISSN1464-2662
DOI
StatusUdgivet - apr. 2019

Bibliografisk note

© 2019 British HIV Association.

ID: 57370526