Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial

Ulla Knorr; Maj Vinberg; Allan Hansen; Marianne Klose; Ulla Feldt-Rasmussen; Linda Hilsted; Jørgen Bo Hasselstrøm; Ulrik Gether; Per Winkel; Christian Gluud; Jørn Wetterslev; Lars Vedel Kessing

doi:10.1371/journal.pone.0021224

Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial

Ulla Knorr, Maj Vinberg, Allan Hansen, Marianne Klose, Ulla Feldt-Rasmussen, Linda Hilsted, Jørgen Bo Hasselstrøm, Ulrik Gether, Per Winkel, Christian Gluud, Jørn Wetterslev, Lars Vedel Kessing

13 Citationer (Scopus)

Abstract

The mechanisms by which selective serotonin re-uptake inhibitors (SSRI) act in depressed patients remain unknown. The serotonergic neurotransmitter system and the hypothalamic-pituitary-adrenal (HPA) system may interact. The aim of the AGENDA trial was to investigate whether long-term intervention with SSRI versus placebo affects the cortisol response in the dexamethasone corticotropin-releasing hormone (DEX-CRH) test in healthy first-degree relatives to patients with major depressive disorder (MDD).

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	6
Udgave nummer	6
Sider (fra-til)	e21224
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0021224
Status	Udgivet - 2011

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Knorr, U., Vinberg, M., Hansen, A., Klose, M., Feldt-Rasmussen, U., Hilsted, L., Hasselstrøm, J. B., Gether, U., Winkel, P., Gluud, C., Wetterslev, J., & Kessing, L. V. (2011). Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial. P L o S One, 6(6), e21224. https://doi.org/10.1371/journal.pone.0021224

Knorr, U , Vinberg, M , Hansen, A , Klose, M , Feldt-Rasmussen, U , Hilsted, L, Hasselstrøm, JB, Gether, U, Winkel, P, Gluud, C, Wetterslev, J & Kessing, LV 2011, 'Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial', P L o S One, bind 6, nr. 6, s. e21224. https://doi.org/10.1371/journal.pone.0021224

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AU - Hilsted, Linda

AU - Hasselstrøm, Jørgen Bo

AU - Gether, Ulrik

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AU - Gluud, Christian

AU - Wetterslev, Jørn

AU - Kessing, Lars Vedel

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KW - Antidepressive Agents

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KW - Family

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Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial

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